HER2在胃癌中的研究进展

被引：8

作者：

刘涛

李燕京

韩宇

机构：

[1] 哈尔滨医科大学附属肿瘤医院内二科

来源：

现代肿瘤医学 | 2015年 / 23卷 / 15期

关键词：

胃癌; HER2; 信号转导; 靶向治疗;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

胃癌病理发展过程复杂,预后较差,化疗效果欠佳。人类表皮生长因子受体2(HER2)与胃癌的相关性、分子靶向治疗是近年来研究的热点,可为探索胃癌的发病机制、临床治疗及预防提供依据。本文就HER2家族的结构、功能、信号转导、针对HER2的靶向药物在胃癌治疗中的研究进展做一综述。

引用

页码：2216 / 2219

页数：4

共 12 条

[1]

HER2阳性胃癌临床病理特征分析 [J].

江慧 ;

宋纯 ;

张桂荣 ;

李奕 ;

袁野 .

中国肿瘤, 2014, 23 (05) :421-425

[2]

HER2在胃癌靶向治疗中的作用及意义.[J].毛必静;张志敏;陈川;王东;王阁;.世界华人消化杂志.2014, 01

[3]

Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma [J].

Sirica, Alphonse E. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (46) :7033-7058

[4]

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 [J].

Ferlay, Jacques ;

Soerjomataram, Isabelle ;

Dikshit, Rajesh ;

Eser, Sultan ;

Mathers, Colin ;

Rebelo, Marise ;

Parkin, Donald Maxwell ;

Forman, David ;

Bray, Freddie .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E359-E386

[5]

Human epidermal growth factor receptor-2 expression in primary and metastatic gastric cancer [J].

Geng, Yiting ;

Chen, Xiaofeng ;

Qiu, Jinrong ;

Zhou, Yue ;

Wang, Jian ;

Liu, Lingxiang ;

Shao, Yongfeng ;

Yin, Yongmei .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2014, 19 (02) :303-311

[6]

Human epidermal growth factor receptor 2 (Her-2) and S-1 adjuvant chemotherapy in stage 2/3 gastric cancer patients who underwent D2 gastrectomy [J].

Aoyama, Toru ;

Yoshikawa, Takaki ;

Miyagi, Yohei ;

Kameda, Yoichi ;

Shirai, Junya ;

Hayashi, Tsutomu ;

Cho, Haruhiko ;

Oshima, Takashi ;

Yukawa, Norio ;

Rino, Yasushi ;

Masuda, Munetaka ;

Tsuburaya, Akira .

SURGERY TODAY, 2013, 43 (12) :1390-1397

[7]

Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study [J].

Sawaki, Akira ;

Ohashi, Yasuo ;

Omuro, Yasushi ;

Satoh, Taroh ;

Hamamoto, Yasuo ;

Boku, Narikazu ;

Miyata, Yoshinori ;

Takiuchi, Hiroya ;

Yamaguchi, Kensei ;

Sasaki, Yasutsuna ;

Nishina, Tomohiro ;

Satoh, Atsushi ;

Baba, Eishi ;

Tamura, Takao ;

Abe, Takashi ;

Hatake, Kiyohiko ;

Ohtsu, Atsushi .

GASTRIC CANCER, 2012, 15 (03) :313-322

[8]

Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[9]

HER2 expression in gastric cancer: Rare; heterogeneous and of no prognostic value – conclusions from 924 cases of two independent series.[J].Heike Grabsch;Shivan Sivakumar;Sally Gray;Helmut E. Gabbert;Wolfram Müller.Cellular Oncology.2010, 1-2

[10]

Comparative Study on Overexpression of HER2/neu and HER3 in Gastric Cancer [J].

Zhang, Xiu Li ;

Yang, Yun Sheng ;

Xu, Dong Ping ;

Qu, Jian Hui ;

Guo, Ming Zhou ;

Gong, Yan ;

Huang, Jin .

WORLD JOURNAL OF SURGERY, 2009, 33 (10) :2112-2118

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