MicroRNA在溃疡性结肠炎活动度和癌变监测中的应用

被引：3

作者：

何昆

钱家鸣

机构：

[1] 中国医学科学院北京协和医学院北京协和医院消化科

来源：

胃肠病学和肝病学杂志 | 2016年 / 25卷 / 10期

关键词：

溃疡性结肠炎; 疾病活动度; 癌变; MicroRNA;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

炎症性肠病(inflammatory bowel disease,IBD)在我国将成为常见病,溃疡性结肠炎(ulcerative colitis,UC)是其主要类型之一。目前UC病情活动度评估和癌变监测主要依赖内镜检查,尚缺乏较理想的实验室指标。MicroRNA(miRNA)是近年发现的非编码小分子RNA,调控炎症、肿瘤等多种生命活动。在UC患者肠组织和外周血中已发现多种与炎症和癌变相关的miRNA,部分机制得到阐明,提示其作为UC相关生物标记(Biomarker)有很好的应用前景。本文就miRNA和UC研究现状作一概述,为寻找UC活动度评估和癌变监测相关miRNA Biomarker提供依据。

引用

页码：1084 / 1087

页数：4

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