Role of microRNAs in the immune system, inflammation and cancer

被引：220

作者：

Raisch, Jennifer ^{[1
,2
]}

Darfeuille-Michaud, Arlette ^{[1
,2
,3
]}

Hang Thi Thu Nguyen ^{[1
,2
]}

机构：

[1] Univ Auvergne, UMR Inserm 1071, M2iSH, F-63000 Clermont Ferrand, France

[2] INRA, USC 2018, F-63000 Clermont Ferrand, France

[3] Ctr Hosp Univ, F-63000 Clermont Ferrand, France

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 20期

关键词：

MicroRNAs; Immune response; Inflammation; Inflammatory bowel disease; Colorectal cancer; COLORECTAL-CANCER; BINDING PROTEIN; NUCLEAR EXPORT; B-CELLS; POSTTRANSCRIPTIONAL REGULATION; TRANSCRIPTIONAL ACTIVATION; ULCERATIVE-COLITIS; TUMOR ANGIOGENESIS; MIR-17-92; CLUSTER; GENE-EXPRESSION;

D O I：

10.3748/wjg.v19.i20.2985

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentiation, development and apoptosis. In addition, microRNAs are coming to light as crucial regulators of innate and adaptive immune responses, and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders, such as inflammatory bowel disease, and cancers. In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. (C) 2013 Baishideng. All rights reserved.

引用

收藏

页码：2985 / 2996

页数：12

相关论文

共 132 条

[1]

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[2]

The Promise of MicroRNA Replacement Therapy [J].

Bader, Andreas G. ;

Brown, David ;

Winkler, Matthew .

CANCER RESEARCH, 2010, 70 (18) :7027-7030

[3]

MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[4]

Identification of the Human Mature B Cell miRNome [J].

Basso, Katia ;

Sumazin, Pavel ;

Morozov, Pavel ;

Schneider, Christof ;

Maute, Roy L. ;

Kitagawa, Yukiko ;

Mandelbaum, Jonathan ;

Haddad, Joseph, Jr. ;

Chen, Chang-Zheng ;

Califano, Andrea ;

Dalla-Favera, Riccardo .

IMMUNITY, 2009, 30 (05) :744-752

[5]

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals [J].

Bazzoni, Flavia ;

Rossato, Marzia ;

Fabbri, Marco ;

Gaudiosi, Daniele ;

Mirolo, Massimiliano ;

Mori, Laura ;

Tamassia, Nicola ;

Mantovani, Alberto ;

Cassatella, Marco A. ;

Locati, Massimo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5282-5287

[6]

Inflammatory Bowel Disease: An Update on the Fundamental Biology and Clinical Management INTRODUCTION [J].

Blumberg, Richard ;

Cho, Judy ;

Lewis, James ;

Wu, Gary .

GASTROENTEROLOGY, 2011, 140 (06) :1701-1703

[7]

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [J].

Bohnsack, MT ;

Czaplinski, K ;

Görlich, D .

RNA, 2004, 10 (02) :185-191

[8]

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease [J].

Brest, Patrick ;

Lapaquette, Pierre ;

Souidi, Mouloud ;

Lebrigand, Kevin ;

Cesaro, Annabelle ;

Vouret-Craviari, Valerie ;

Mari, Bernard ;

Barbry, Pascal ;

Mosnier, Jean-Francois ;

Hebuterne, Xavier ;

Harel-Bellan, Annick ;

Mograbi, Baharia ;

Darfeuille-Michaud, Arlette ;

Hofman, Paul .

NATURE GENETICS, 2011, 43 (03) :242-U24

[9]

The complexities of microRNA regulation: mirandering around the rules [J].

Breving, Kimberly ;

Esquela-Kerscher, Aurora .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (08) :1316-1329

[10]

The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function [J].

Brueckner, Bodo ;

Stresemann, Carlo ;

Kuner, Ruprecht ;

Mund, Cora ;

Musch, Tanja ;

Meister, Michael ;

Sueltmann, Holger ;

Lyko, Frank .

CANCER RESEARCH, 2007, 67 (04) :1419-1423

← 1 2 3 4 5 6 7 8 9 10 →