The Promise of MicroRNA Replacement Therapy

被引：486

作者：

Bader, Andreas G. ^{[1
]}

Brown, David ^{[1
]}

Winkler, Matthew ^{[2
]}

机构：

[1] Mirna Therapeut Inc, Austin, TX 78744 USA

[2] Asuragen Inc, Austin, TX USA

来源：

CANCER RESEARCH | 2010年 / 70卷 / 18期

关键词：

SUPPRESSION; PROFILES;

D O I：

10.1158/0008-5472.CAN-10-2010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNA), a class of natural RNA-interfering agents, have recently been identified as attractive targets for therapeutic intervention. The rationale for developing miRNA therapeutics is based on the premise that aberrantly expressed miRNAs play key roles in the development of human disease, and that correcting these miRNA deficiencies by either antagonizing or restoring miRNA function may provide a therapeutic benefit. Although miRNA antagonists are conceptually similar to other inhibitory therapies, restoring the function of a miRNA by miRNA replacement is a less well characterized approach. Here, we discuss the specific properties of miRNA replacement and review recent examples that explored the therapeutic delivery of miRNA mimics in animal models of cancer. Cancer Res; 70(18); 7027-30. (C)2010 AACR.

引用

收藏

页码：7027 / 7030

页数：4

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