PI3K-Akt信号通路与肿瘤细胞凋亡关系的研究进展

被引：113

作者：

黄秀兰

崔国辉

周克元

机构：

[1] 广东医学院生物化学与分子生物学研究所

来源：

癌症 | 2008年 / 03期

关键词：

PI3K-Akt; 信号转导; 细胞凋亡; 肿瘤; 靶向治疗;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学]; R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

PI3K-Akt信号通路作为细胞内重要信号转导通路之一,通过影响下游多种效应分子的活化状态,在细胞内发挥着抑制凋亡、促进增殖的关键作用,它与人类多种肿瘤的发生发展密切相关。本文综述了PI3K-Akt信号通路的组成与功能、调节以及其抗肿瘤细胞凋亡作用机理等方面的研究进展,并就其抗细胞凋亡作用在肿瘤治疗中的应用作了评述,期待为以PI3K-Akt信号通路中关键分子为靶点的肿瘤治疗研究提供参考。

引用

页码：331 / 336

页数：6

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