肝细胞肝癌相关蛋白质组学研究进展

被引:1
作者
吴益峰
孙德光
王立明
机构
[1] 大连医科大学附属第二医院普外三科
关键词
肝细胞性肝癌; 蛋白质组学; 肿瘤标志物;
D O I
暂无
中图分类号
R735.7 [肝肿瘤];
学科分类号
摘要
探讨和揭示肝细胞肝癌发生发展和转移复发的相关因素及分子机制,寻找早期诊断肝癌、预测转移的生物标记和干预治疗的药物靶点,已成为当今肝细胞肝癌研究的热点。随着后基因组时代的来临,作为功能基因的直接体现者及生物体生命功能执行者的蛋白质为多基因、多蛋白的肝细胞肝癌的研究创造了新的契机。
引用
收藏
页码:3681 / 3684
页数:4
相关论文
共 10 条
  • [1] 采用定量蛋白质组学技术筛选小鼠肝癌淋巴道转移相关蛋白
    孙成荣
    唐建武
    孙明忠
    刘淑清
    张宏颖
    王波
    宋波
    张亚楠
    张竹清
    赵志英
    [J]. 生物化学与生物物理进展, 2007, (08) : 856 - 864
  • [2] 肝癌亚细胞结构的蛋白质组分比较分析
    李兴
    潘卫
    邱峰
    邱宗荫
    [J]. 分子细胞生物学报, 2006, (05) : 399 - 406
  • [3] Proteomic Analysis of HCV Cirrhosis and HCV-Induced HCC: Identifying Biomarkers for Monitoring HCV-Cirrhotic Patients Awaiting Liver Transplantation[J] . Valeria R. Mas,Daniel G. Maluf,Kellie J. Archer,Kenneth Yanek,Karen Bornstein,Robert A. Fisher.Transplantation . 2009 (1)
  • [4] Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma
    Lee, Nikki P. Y.
    Leung, Kar-Wai
    Cheung, Nicole
    Lam, Brian Y.
    Xu, Michelle Z.
    Sham, Pak C.
    Lau, George K.
    Poon, Ronnie T. P.
    Fan, Sheung Tat
    Luk, John M.
    [J]. PROTEOMICS, 2008, 8 (10) : 2136 - 2149
  • [5] Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma
    Zhang, Daohai
    Lim, Seng Gee
    Koay, Evelyn S. C.
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2007, 31 (03) : 577 - 584
  • [6] Identification of human hepatocellular carcinoma-related proteins by proteomic approaches
    Yang, Ming-Hui
    Tyan, Yu-Chang
    Jong, Shiang-Bin
    Huang, Ying-Fong
    Liao, Pao-Chi
    Wang, Ming-Chen
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2007, 388 (03) : 637 - 643
  • [7] Heat‐shock protein 27: A potential biomarker for hepatocellular carcinoma identified by serum proteome analysis[J] . Ju‐TaoFeng,Yin‐KunLiu,Hai‐YanSong,ZhiDai,Lun‐XiuQin,Mohamad RadwanAlmofti,Cai‐YunFang,Hao‐JieLu,Peng‐YuanYang,Zhao‐YouTang.Proteomics . 2005 (17)
  • [8] Proteomics: quantitative and physical mapping of cellular proteins[J] . Walter P Blackstock,Malcolm P Weir.Trends in Biotechnology . 1999 (3)
  • [9] Aquantitative analysis of mitochondrial pro-tein differential expressions in hydroxycamptothecin-treated hepatoma cells. Yan YR,Fu YR,Qiu ZY. Chinese Journal of Hepatology . 2008
  • [10] Analysis of micro-dissected cells by two-dimensional LC-MS approaches. Li C,Yi-Hong,Tan YX,et al. Methods in Molecular Biology . 2008