脑出血脑组织中水通道蛋白4的极性表达缺失

被引：6

作者：

邱国平

孙善全

卓飞

徐进

刘辉

杨美

机构：

[1] 重庆医科大学基础医学院解剖学教研室

来源：

重庆医科大学学报 | 2015年 / 40卷 / 05期

关键词：

水通道蛋白; 脑出血; 脑水肿; 极性表达;

D O I：

10.13406/j.cnki.cyxb.000572

中图分类号：

R743.34 [脑出血];

学科分类号：

摘要：

目的:观察脑出血(intracerebral hemorrhage,ICH)大鼠脑组织中水通道蛋白4(aquaporin 4,AQP4)的极性表达变化情况,以初步探讨其在出血性脑水肿中的作用。方法:SD大鼠随机分为sham组和ICH组,采用自体血注入法建立大鼠ICH动物模型,应用核磁共振成像检测血肿产生及发展情况,干湿重法检测脑水含量变化以及免疫荧光检测AQP4的极性表达变化情况。结果:ICH后1 d,血肿体积最大,脑水含量达到峰值,高达(79.769±0.710)%,差值具有统计学意义(P=0.000);血肿周围组织中AQP4极性表达缺失,AQP4表达在星胶细胞胞体和突起上,而sham组中AQP4则极性表达在星胶细胞终足膜上。结论:ICH后血肿周围组织中AQP4极性表达缺失,后者可能促进了出血性脑水肿的发生。

引用

页码：666 / 670

页数：5

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