和厚朴酚最新药理学研究进展与评述

被引：35

作者：

林琳 ^{[1
]}

丁一 ^{[2
]}

机构：

[1] 口腔疾病研究国家重点实验室四川大学

[2] 四川大学华西口腔医院牙周科

来源：

中药药理与临床 | 2011年 / 27卷 / 01期

关键词：

和厚朴酚; 药理学; 临床应用;

D O I：

10.13412/j.cnki.zyyl.2011.01.040

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

和厚朴酚是厚朴的最主要的活性组分之一。和厚朴酚具有明显而持久的抗菌、抗氧化、抗炎、抗肿瘤、抗痉挛、抗焦虑和抗病毒等药理作用,临床应用于治疗急性肠炎、慢性胃炎等。本文综述了和厚朴酚药理学方面的最新研究进展。

引用

页码：110 / 113

页数：4

共 23 条

[1] 厚朴活性成分对致龋菌生长和产酸影响的体外研究 [J].

冯瑾 ;

李继遥 ;

周学东 .

四川大学学报(医学版), 2007, (03) :456-458

[2]

Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin[J]. He HU~1 Xiao-xue ZHANG~1 Yin-ye WANG~(1,2) Shi-zhong CHEN~31 Department of Molecular and Cellular Pharmacology Beijing University Beijing 100083,China;3 Department of Natural Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University Beijing 100083,China.Acta Pharmacologica Sinica. 2005(09)

[3] Synthesis and Microbiological Evaluation of Honokiol Derivatives as New Antimicrobial Agents [J].

Kim, Young-Soo ;

Lee, Ji-Young ;

Park, Junho ;

Hwang, Wangtaek ;

Lee, Jongsung ;

Park, Deokhoon .

ARCHIVES OF PHARMACAL RESEARCH, 2010, 33 (01) :61-65

[4] Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation [J].

Schuehly, Wolfgang ;

Huefner, Antje ;

Pferschy-Wenzig, Eva M. ;

Prettner, Elke ;

Adams, Michael ;

Bodensieck, Antje ;

Kunert, Olaf ;

Oluwemimo, Asije ;

Haslinger, Ernst ;

Bauer, Rudolf .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (13) :4459-4465

[5] Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol [J].

Luo, Youfu ;

Xu, Yongbin ;

Chen, Lijuan ;

Hu, Jia ;

Peng, Cheng ;

Xie, DaChun ;

Shi, Jianyou ;

Huang, Wencai ;

Xu, Guobin ;

Peng, Ming ;

Han, Jing ;

Li, Rui ;

Yang, Shengyong ;

Wei, Yuquan .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (16) :4702-4705

[6] Effect of honokiol and 5-FU on non-melanoma skin cancer cells [J].

Ainbinder, D. ;

Protokin, R. ;

Chaouat, M. ;

Touitou, E. .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2009, 19 (04) :283-287

[7]

Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer[J] . Hong Luo,Qian Zhong,Li-juan Chen,Xiao-rong Qi,A-fu Fu,Han-shuo Yang,Fan Yang,Hong-gang Lin,Yu-quan Wei,Xia Zhao.Journal of Cancer Research and Clinical Oncology . 2008 (9)

[8]

Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer[J] . Hongyu Liu,Chuanbing Zang,Anna Emde,Maricarmen D. Planas-Silva,Marleen Rosche,Andrea Kühnl,Carsten-Oliver Schulz,Elena Elstner,Kurt Possinger,Jan Eucker.European Journal of Pharmacology . 2008 (1)

[9] Honokiol is a potent scavenger of superoxide and peroxyl radicals [J].

Dikalov, Sergey ;

Losik, Tanya ;

Arbiser, Jack L. .

BIOCHEMICAL PHARMACOLOGY, 2008, 76 (05) :589-596

[10]

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells[J] . Zhengyu Li,Yi Liu,Xia Zhao,Xiaoling Pan,Rutie Yin,Canhua Huang,Lijuan Chen,Yuquan Wei.European Journal of Obstetrics and Gynecology . 2008 (1)

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