Synthesis and Microbiological Evaluation of Honokiol Derivatives as New Antimicrobial Agents

被引：47

作者：

Kim, Young-Soo ^{[1
]}

Lee, Ji-Young ^{[1
]}

Park, Junho ^{[1
]}

Hwang, Wangtaek ^{[1
]}

Lee, Jongsung ^{[1
]}

Park, Deokhoon ^{[1
]}

机构：

[1] Biospectrum Life Sci Inst, Gunpo 435833, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 01期

关键词：

Honokiol derivatives; Anti-bacterial; Escherichia coli; Pseudomonas aeruginosa; MAGNOLIA-OFFICINALIS; IN-VITRO;

D O I：

10.1007/s12272-010-2225-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Honokiol, a major phenolic constituent of Magnolia sp., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-derivatives (honokiol-acetate, honokiol-succinic acid, honokiol-glycerol, honokiol-glycine, honokiol-glucose and honokiol-mannose) were synthesized and their solubility and antimicrobial activities were investigated. Among the tested compounds, honokiol-glycine showed improved water solubility and antibacterial activities against E. coli and P. aeruginosa when compared to honokiol.

引用

页码：61 / 65

页数：5

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