糖尿病肾病致凝血异常的研究

被引：14

作者：

于牧鑫

马瑞爽

司宇

吴晓明

邓瑞娟

张妍

史文杰

解汝娟

机构：

[1] 哈尔滨医科大学附属第一医院

来源：

现代生物医学进展 | 2015年 / 15卷 / 19期

关键词：

糖尿病肾病; 凝血功能异常; 高凝状态;

D O I：

10.13241/j.cnki.pmb.2015.19.050

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

糖尿病(DM)已成为世界性的常见病,其发病率高,并且随着生活水平的改善,其发病率必然还会进一步加剧。血管病变是DM的重要并发症之一,糖尿病肾病(DN)是糖尿病常见且严重的微血管并发症,与血栓形成密切相关。糖尿病肾病的进展伴随着体内凝血活性和抗凝活性的失调,同时激活自身免疫系统,发生炎症反应。炎症应答过程中释放的炎症因子损伤肾小球内皮细胞,导致抗凝活性减弱。DN患者体内血细胞激活,微粒形成增多会加强凝血活性。此外,纤溶酶抑制剂(PAI-1)与纤溶酶激活剂(t PA)的失衡会引起纤溶系统紊乱。这三个方面引起DN患者体内的高凝状态加重,并因此加速肾功能恶化,导致肾小球率过滤降低,系膜基质增多,最终引起肾小球硬化及终末期肾脏疾病。本文就糖尿病肾病致凝血异常的发生机制做一综述。

引用

页码：3784 / 3785+3793 +3793

页数：3

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