新型强效自由基清除剂依达拉奉治疗急性缺血性卒中——从实验室到临床

被引：7

作者：

樊东升

机构：

[1] 北京大学第三医院神经内科

来源：

国际脑血管病杂志 | 2009年 / 01期

关键词：

依达拉奉; 缺血性卒中; 神经保护; 抗氧化剂; 自由基清除剂;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

自由基在缺血性脑损伤过程中起着关键作用,通过不饱和脂肪酸过氧化反应加重细胞膜损伤,进而导致神经元死亡和脑水肿。依达拉奉是一种新型强效自由基清除剂,可通过抑制脑缺血区内皮损伤和缓解神经细胞损害发挥神经保护作用,还能减轻溶栓治疗诱导的再灌注后脑水肿和出血事件。临床经验提示,依达拉奉的治疗时间窗很宽,与溶栓疗法联合应用能降低卒中病死率和促进神经功能缺损的恢复文章对依达奉从实验室到临床阶段的发展历程做了综述。

引用

页码：1 / 6

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