基于气相/液相色谱-高分辨率质谱联用技术的非目标化合物分析方法研究进展

被引:14
作者
林必桂 [1 ,2 ]
于云江 [1 ,2 ]
向明灯 [1 ,2 ]
余乐洹 [2 ]
李良忠 [2 ]
鞠勇明 [2 ]
玉琳 [2 ]
机构
[1] 有机地球化学国家重点实验室中国科学院广州地球化学研究所
[2] 环境保护部华南环境科学研究所
关键词
非目标化合物分析; 目标化合物分析; 高分辨率质谱; 解卷积软件; 数据库; 高通量筛选;
D O I
暂无
中图分类号
O657.63 [质谱分析];
学科分类号
070302 ; 081704 ;
摘要
近10多年来随着色谱(气相色谱和液相色谱)和高分辨率质谱联用技术以及相关数据处理软件和数据库的发展,使得高通量的非目标化合物分析方法得以实现,并在环境研究、食品监管、药物研发以及生物代谢物研究等领域得到日益广泛的应用.本文综述了基于气相/液相色谱-高分辨率质谱联用技术的非目标化合物分析方法的研究进展,包括其分析方法策略、流程及其在环境研究领域的实际应用情况,并探讨了该方法所存在的问题和发展前景,为环境中的新兴污染物及其代谢转化产物、关键致毒物的甄别、环境健康风险评估等提供一种新兴的高通量分析鉴别技术.
引用
收藏
页码:466 / 476
页数:11
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