microRNA介导肿瘤多药耐药及中药的作用

被引：4

作者：

张瑞娟

许建华

余文燕

王国娟

孙珏

范忠泽

机构：

[1] 上海中医药大学附属普陀医院

来源：

世界科学技术-中医药现代化 | 2013年 / 07期

关键词：

微小RNA; 多药耐药; 肿瘤; 综述;

D O I：

暂无

中图分类号：

R273 [中医肿瘤科];

学科分类号：

摘要：

microRNA(简称miRNA)能通过诱导mRNA裂解或抑制mRNA翻译从而在转录后水平调控基因表达,参与细胞发育、增殖、分化、凋亡等一系列重要生物学进程。近期研究发现miRNA对靶基因的异常调控可能参与肿瘤耐药,有望成为重要的肿瘤耐药相关分子标记物及治疗靶点。中药及其有效成分可影响miRNA进而调控相应靶蛋白和靶基因介导肿瘤多药耐药,为中药逆转多药耐药的机制研究提供新思路。

引用

页码：1515 / 1520

页数：6

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