Small RNAs and cancerogenesis

被引：22

作者：

Ryazansky, S. S. ^{[1
]}

Gvozdev, V. A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 05期

关键词：

miRNA; siRNA; cancerogenesis; epigenome;

D O I：

10.1134/S0006297908050040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disturbances of microRNA generation and functioning as inhibitors of gene expression at the translational level are considered as specific and diagnostic features of cancer. This review also highlights the role of short interfering RNA (siRNA) in modified epigenomic chromatin structure, which may cause cancer transformation. Future directions of cancer epigenomics are considered in the light of the involvement of siRNA in epigenomic modification of chromatin.

引用

页码：514 / 527

页数：14

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