槲皮素的生物活性机制及药动学特点

被引：16

作者：

廖瀚

甄宇红

丁超

龙亚一

丰雪

机构：

[1] 大连医科大学药学院

来源：

现代生物医学进展 | 2012年 / 12卷 / 16期

关键词：

槲皮素; 药动学; 生物活性;

D O I：

10.13241/j.cnki.pmb.2012.16.012

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

近年来,许多文献报道了槲皮素发挥生物活性的机制,发现槲皮素并不只是通过抗氧化机制发挥活性。细胞因子及细胞信号转导在槲皮素发挥生物活性的过程中也起到了重要作用。另一方面,有研究表明,口服生物利用度不高、首关效应强是阻碍食物中槲皮素充分发挥生物活性的重要原因。然而,槲皮素的体内分布和代谢特征又给予它发挥在体活性的潜力。因此,槲皮素很有研究价值。本文主要介绍槲皮素的作用机制,并阐述其药动学特点,为人们对槲皮素的进一步研究提供参考。

引用

页码：3174 / 3177+3190 +3190

页数：5

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