蒙特利尔认知评估量表在中国帕金森氏病患者中筛查痴呆的应用(英文)

被引:20
作者
陈伶 [1 ]
于翠玉 [2 ]
符晓苏 [1 ]
刘卫国 [2 ]
华平 [2 ]
张宁 [2 ]
郭昇翰 [3 ]
机构
[1] 江苏省省级机关医院
[2] 南京医科大学附属脑科医院
[3] 哥伦比亚大学
关键词
蒙特利尔认知评估量表; 帕金森; PD; 帕金森氏症; MMSE; 筛查; 患者; 帕金森病; 中华人民共和国;
D O I
暂无
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
摘要
背景:痴呆是帕金森氏病(PD)相关的最痛苦和最繁重的健康问题之一。蒙特利尔认知评估量表(MOCA)被广泛用于帕金森氏症患者的痴呆筛查,但是不知道怎样的诊断划界分适用于中国的帕金森病患者。目的:确定中国版蒙特利尔认知评估量表(MoCA-C)在中国帕金森氏症患者中的诊断划界分和了解经MoCA-C筛查痴呆阳性的帕金森氏症患者的特征方法:采用运动障碍学会工作组标准(金标准诊断)确定616例PD患者和85名社区对照中是否存在痴呆。我们对这些人进行了MoCA-C测试,并运用受试者工作特征(ROC)曲线来确定能够最有效地识别帕金森氏症患者和社区对照中痴呆的MoCA-C划界分。比较经MoCA-C筛查为痴呆阳性与阴性的PD患者的人口学和临床特征。结果:MoCA-C 23分是诊断帕金森氏患者及对照组痴呆的最佳划界分。使用该划界分,PD患者的MoCA-C敏感性和特异性分别为0.70和0.77,阳性和阴性预测值分别为0.59和0.85,整体一致性(kappa[95%可信区间])为0.45(0.39-0.52)。社区对照相应的kappa值(一致性)仅为0.25(0.05-0.45)。与筛查为痴呆阴性的PD患者相比,筛查为痴呆阳性的PD患者所有认知功能都有显著受损,包括视觉空间和执行功能,命名,注意力,语言,抽象,延迟回忆和定向(均P<0.001)。在帕金森氏症患者中,筛查为痴呆阳性与年老,文化程度低,女性以及严重运动障碍独立相关。结论:通常建议的痴呆划界分26对于中国帕金森病患者来说过高;23分划界分更加合适。中国的帕金森氏症患者发生痴呆的可能危险因素包括年龄,文化程度较低,以及PD严重的运动障碍症状。
引用
收藏
页码:296 / 305
页数:10
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