续断提取物对骨质疏松性大鼠信号通路作用的研究进展

被引：22

作者：

金芳全 ^{[1
]}

樊成虎 ^{[2
]}

唐晓栋 ^{[2
]}

陈彦同 ^{[2
]}

齐兵献 ^{[2
]}

胡星荣 ^{[2
]}

机构：

[1] 甘肃中医药大学

[2] 甘肃省中医院

来源：

中国骨质疏松杂志 | 2023年 / 29卷 / 07期

关键词：

中医中药; 骨质疏松症; 续断; 木通皂苷D; 骨髓间充质干细胞; 信号通路;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

骨质疏松症(osteoporosis, OP)是骨吸收大于骨形成的骨代谢疾病，随着全球老龄化加重，严重威胁人类健康安全。续断作为传统补肾中药在防治OP方面具有广阔潜力，有关研究表明续断通过多靶点、多途径调控相关信号通路防治OP。最新药理学研究证明续断提取物木通皂苷D等成分可通过调控有关信号通路和促炎因子干预碱性磷酸酶、骨保护蛋白、骨钙素等蛋白因子表达，作用于成骨细胞、破骨细胞以及骨髓间充质干细胞有效防治OP。通过检索续断提取物防治OP的基础研究发现，续断提取物木通皂苷D、熊果酸、多糖类可以通过Wnt/β-catenin、MAPK、PI3K/AKT、BMP-Smads信号通路促骨形成，通过OPG/RANKL/RANK、雌激素信号通路抑制骨吸收防治OP。笔者就续断提取物调控不同信号通路，促进成骨细胞增殖，抑制破骨细胞分化，诱导骨髓间充质干细胞定向分化作一综述，为今后中医药防治OP的基础研究提供新思路。

引用

页码：1016 / 1020

页数：5

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