Prevalence of Osteoporosis and Fracture in China The China Osteoporosis Prevalence Study

被引：766

作者：

Wang, Linhong ^{[2
]}

Yu, Wei ^{[3
]}

Yin, Xiangjun ^{[4
]}

Cui, Lijia ^{[1
]}

Tang, Shunyu ^{[4
]}

Jiang, Ning ^{[1
]}

Cui, Lu ^{[4
]}

Zhao, Nan ^{[5
]}

Lin, Qiang ^{[3
]}

Chen, Lin ^{[6
]}

Lin, Hua ^{[7
]}

Jin, Xiaolan ^{[8
]}

Dong, Zhong ^{[9
]}

Ren, Zeping ^{[10
]}

Hou, Zhulin ^{[11
]}

Zhang, Yongqing ^{[12
]}

Zhong, Jieming ^{[13
]}

Cai, Shunxiang ^{[14
]}

Liu, Yuan ^{[15
]}

Meng, Ruilin ^{[16
]}

Deng, Ying ^{[17
]}

Ding, Xianbin ^{[18
]}

Ma, Jingang ^{[19
]}

Xie, Zhongjian ^{[20
]}

Shen, Lin ^{[21
]}

Wu, Wen ^{[22
]}

Zhang, Mengmeng ^{[23
]}

Ying, Qifeng ^{[24
]}

Zeng, Yuhong ^{[25
]}

Dong, Jin ^{[26
]}

Cummings, Steven R. ^{[27
]}

Li, Zhixin ^{[2
]}

Xia, Weibo ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Natl Commiss Hlth, Dept Endocrinol,Key Lab Endocrinol, 1 Shuaifuyuan, Beijing 100730, Peoples R China

[2] Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pr, 27 Nanwei Rd, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China

[4] Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pr, Div Elderly Hlth, Beijing, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Med Sci Res Ctr, Beijing, Peoples R China

[6] Army Med Univ, Daping Hosp, Dept Wound Repair & Rehabil Med, State Key Lab Trauma Burns & Combined Injury, Chongqing, Peoples R China

[7] Nanjing Univ, Dept Orthopaed, Jiangsu Prov, Nanjing Drum Tower Hosp,Med Sch,Affiliated Hosp, Nanjing, Jiangsu, Peoples R China

[8] Chengdu Mil Gen Hosp, Dept Endocrinol, Chengdu, Sichuan, Peoples R China

[9] Beijing Ctr Dis Prevent & Control, Beijing, Peoples R China

[10] Shanxi Prov Ctr Dis Control & Prevent, Taiyuan, Shanxi, Peoples R China

[11] Jilin Prov Ctr Dis Control & Prevent, Changchun, Jilin, Peoples R China

[12] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China

[13] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

[14] Hubei Prov Ctr Dis Control & Prevent, Wuhan, Hubei, Peoples R China

[15] Hunan Prov Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China

[16] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China

[17] Sichuan Ctr Dis Control & Prevent, Chengdu, Sichuan, Peoples R China

[18] Chongqing Ctr Dis Control & Prevent, Chongqing, Peoples R China

[19] Shaanxi Prov Ctr Dis Control & Prevent, Xian, Shaanxi, Peoples R China

[20] Cent South Univ, Natl Clin Res Ctr Metab Dis, Dept Metab & Endocrinol, Hunan Prov Key Lab Metab Bone Dis,Xiangya Hosp 2, Changsha, Hunan, Peoples R China

[21] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Integrated Tradit Chinese & Western Med, Wuhan, Hubei, Peoples R China

[22] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Prov Geriatr Inst, Dept Endocrinol, Guangzhou, Guangdong, Peoples R China

[23] Jilin FAW Gen Hosp, Dept Osteoporosis, Changchun, Jilin, Peoples R China

[24] Zhejiang Prov Peoples Hosp, Ctr Osteoporosis, Hangzhou, Zhejiang, Peoples R China

[25] Xi An Jiao Tong Univ, Honghui Hosp, Dept Osteoporosis, Xian, Shaanxi, Peoples R China

[26] Shanxi Med Univ, Dept Endocrinol, Affiliated Hosp 1, Taiyuan, Shanxi, Peoples R China

[27] Calif Pacific Med Ctr, San Francisco Coordinating Ctr, Res Inst, San Francisco, CA USA

来源：

JAMA NETWORK OPEN | 2021年 / 4卷 / 08期

关键词：

BONE-MINERAL DENSITY; VERTEBRAL FRACTURE; NATIONAL-HEALTH; RISK-FACTORS; HONG-KONG; WOMEN; MEN; HIP; US; DIAGNOSIS;

D O I：

10.1001/jamanetworkopen.2021.21106

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

IMPORTANCE The aging of the population is associated with an increasing burden of fractures worldwide. However, the epidemiological features of fractures in mainland China are not well known. OBJECTIVE To assess the prevalence of and factors associated with osteoporosis, clinical fractures, and vertebral fractures in an adult population 40 years or older in mainland China. DESIGN, SETTING. AND PARTICIPANTS This cross-sectional study, the China Osteoporosis Prevalence Study, was conducted from December 2017 to August 2018. A random sample of individuals aged 20 years or older who represented urban and rural areas of China were enrolled, with a 99% participation rate. MAIN OUTCOMES AND MEASURES Weighted prevalence of osteoporosis, clinical fracture, and vertebral fracture by age, sex, and urban vs rural residence as determined by x-ray absorptiometry, questionnaire, and radiography. RESULTS A total of 20 416 participants were included in this study; 20 164 (98.8%; 11 443 women [56.7%]; mean [SD] age, 53 [13] years) had a qualified x-ray absorptiometry image and completed the questionnaire, and 8423 of 8800 (95.7%) had a qualified spine radiograph. The prevalence of osteoporosis among those aged 40 years or older was 5.0% (95% CI, 4.2%-5.8%) among men and 20.6% (95% CI, 19.3%-22.0%) among women. The prevalence of vertebral fracture was 10.5% (95% CI, 9.0%-12.0%) among men and 9.7% (95% CI, 8.2%-11.1%) among women. The prevalence of clinical fracture in the past 5 years was 4.1% (95% CI, 3.3%-4.9%) among men and 4.2% (95% CI, 3.6%-4.7%) among women. Among men and women, 0.3% (95% CI, 0.0%-0.7%) and 1.4% (95% CI, 0.8%-2.0%), respectively, with osteoporosis diagnosed on the basis of bone mineral density or with fracture were receiving antiosteoporosis treatment to prevent fracture. CONCLUSIONS AND RELEVANCE In this cross-sectional study of an adult population in mainland China, the prevalence of osteoporosis and vertebral fracture were high and the prevalence of vertebral fracture and clinical fracture was similarly high in men and women. These findings suggest that current guidelines for screening and treatment of fractures among patients in China should focus equally on men and women and should emphasize the prevention of vertebral fractures.

引用

页数：12

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