他汀类药物与氯吡格雷相互作用争议的现状

被引:20
作者
王燕慧 [1 ]
张灏 [2 ]
机构
[1] 甘肃省第二人民医院重症监护室
[2] 甘肃省第二人民医院心内科
关键词
氯吡格雷; 他汀类药物; 肝细胞色素P450; 急性冠脉综合征; 经皮冠状动脉介入治疗;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
近年来大规模随机试验证实,他汀类药物具有多效性,在冠心病的一级和二级预防中具有肯定的效果,并且强化他汀类药物的治疗在急性冠脉综合征(ACS)和经皮冠脉介入治疗(PCI)中有重要价值。阿司匹林联合应用氯吡格雷能进一步减少ACS和PCI患者的血栓并发症。临床上已经将强化他汀类药物和双重抗血小板治疗应用于ACS和PCI患者,并取得了较理想的效果。但一些小样本研究提示他汀类药物和氯吡格雷合用竞争肝细胞色素P450同工酶CYP3A4而降低氯吡格雷抗血小板的能力,但多数研究显示,阿托伐他汀等经CYP3A4代谢的他汀和氯吡格雷同时使用并不降低氯毗格雷的抗血小板作用。该文就他汀类药物与氯吡格雷相互作用的争议进行综述。
引用
收藏
页码:104 / 107
页数:4
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