冠状病毒入胞途径的研究进展

被引：36

作者：

王欢

丁铲

廖瑛

机构：

[1] 中国农业科学院上海兽医研究所

来源：

病毒学报 | 2019年 / 35卷 / 06期

关键词：

冠状病毒; 受体; 内吞作用; 抗病毒药物;

D O I：

10.13242/j.cnki.bingduxuebao.003586

中图分类号：

S852.65 [家畜病毒学];

学科分类号：

090507 [智慧养殖与动物生产学];

摘要：

冠状病毒家族成员众多,主要感染哺乳动物和禽鸟类,给人类和动物的健康带来了极大危害。病毒对细胞表面受体的结合和内吞方式,决定病毒的宿主范围、组织嗜性和发病机理;此外,研究病毒的入胞途径不仅有助于我们认识病毒的生活周期,还对病毒性感染的预防和治疗具有重要意义。本文总结归纳了近十年来冠状病毒入胞途径的研究进展:多数冠状病毒可通过网格蛋白依赖型内吞、小窝蛋白依赖型内吞、巨胞饮以及网格蛋白/小窝蛋白非依赖型内吞途径进入细胞,到达早期内体、晚期内体或溶酶体等处发生膜融合,释放病毒基因组进入细胞质。病毒的内吞途径可作为广谱抗病毒药物设计的靶点。

引用

页码：964 / 971

页数：8

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