PTEN缺失在诱导大肠腺瘤样息肉产生及恶性演变机制中的作用

被引：10

作者：

平倩

张涛

陈玉

林春李

刘鹏

陈远能

机构：

[1] 广西中医药大学附属瑞康医院消化内科

来源：

实用医学杂志 | 2015年 / 31卷 / 19期

关键词：

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

摘要：

<正>Morson[1]提出"腺瘤-癌"顺序学说,该学说支持大肠癌是由腺瘤发展而来的观点,而由腺瘤发展为大肠癌一般为10～15年。大肠腺瘤性息肉可分为管状腺瘤、绒毛状腺瘤和混合性腺瘤[2]。近年来我国大肠癌发病和病死率均呈上升趋势[3],因而早期发现大肠息肉具有重要意义。大肠息肉的发病机制尚未完全明晰,Yip等[4]研究发现PTEN在大肠息肉的发生及恶变中占据重要的地位,约12%78%的大肠息肉患者随着病理类型的差异而有不同程度的PTEN表

引用

页码：3123 / 3125

页数：3

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