Tenets of PTEN tumor suppression

被引：941

作者：

Salmena, Leonardo ^{[1
,2
]}

Carracedo, Arkaitz ^{[1
,2
]}

Pandolfi, Pier Paolo ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Canc Genet Program, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Canc Genet Program, Boston, MA 02115 USA

来源：

CELL | 2008年 / 133卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.

引用

收藏

页码：403 / 414

页数：12

相关论文

共 122 条

[1] Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β [J].

Al-Khouri, AM ;

Ma, YL ;

Togo, SH ;

Williams, S ;

Mustelin, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35195-35202

[2] Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity [J].

Ali, IU ;

Schriml, LM ;

Dean, M .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22) :1922-1932

[3] Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease [J].

Backman, SA ;

Stambolic, V ;

Suzuki, A ;

Haight, J ;

Elia, A ;

Pretorius, J ;

Tsao, MS ;

Shannon, P ;

Bolon, B ;

Ivy, GO ;

Mak, TW .

NATURE GENETICS, 2001, 29 (04) :396-403

[4] PTEN, more than the AKT pathway [J].

Blanco-Aparicio, Carmen ;

Renner, Oliver ;

Leal, Juan F. M. ;

Carnero, Amancio .

CARCINOGENESIS, 2007, 28 (07) :1379-1386

[5] Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas [J].

Bose, S ;

Wang, SI ;

Terry, MB ;

Hibshoosh, H ;

Parsons, R .

ONCOGENE, 1998, 17 (01) :123-127

[6] PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms [J].

Brognard, John ;

Sierecki, Emma ;

Gao, Tianyan ;

Newton, Alexandra C. .

MOLECULAR CELL, 2007, 25 (06) :917-931

[7] Cellular senescence: when bad things happen to good cells [J].

Campisi, Judith ;

di Fagagna, Fabrizio d'Adda .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (09) :729-740

[8] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

[9] Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1 [J].

Chappell, WH ;

Green, TD ;

Spengeman, JD ;

McCubrey, JA ;

Akula, SM ;

Bertrand, FE .

CELL CYCLE, 2005, 4 (10) :1389-1395

[10] Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis [J].

Chen, ZB ;

Trotman, LC ;

Shaffer, D ;

Lin, HK ;

Dotan, ZA ;

Niki, M ;

Koutcher, JA ;

Scher, HI ;

Ludwig, T ;

Gerald, W ;

Cordon-Cardo, C ;

Pandolfi, PP .

NATURE, 2005, 436 (7051) :725-730

← 1 2 3 4 5 6 7 8 9 10 →