Tenets of PTEN tumor suppression

被引：941

作者：

Salmena, Leonardo ^{[1
,2
]}

Carracedo, Arkaitz ^{[1
,2
]}

Pandolfi, Pier Paolo ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Canc Genet Program, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol,Canc Genet Program, Boston, MA 02115 USA

来源：

CELL | 2008年 / 133卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.

引用

收藏

页码：403 / 414

页数：12

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