膳食甘油二酯对SD大鼠食欲及下丘脑神经肽Y基因表达的影响

被引：3

作者：

向雪松

曹子鹏

曹瑞

丁烨

侯祥红

张文斌

王枫

机构：

[1] 第四军医大学营养与食品卫生学教研室

来源：

现代生物医学进展 | 2007年 / 04期

关键词：

1,3一甘油二酯; 甘油三酯; NPY;

D O I：

10.13241/j.cnki.pmb.2007.04.016

中图分类号：

R151 [营养学];

学科分类号：

摘要：

研究膳食甘油二酯对SD大鼠食欲和下丘脑神经肽Y基因表达的影响。方法:将大鼠随机分成三组:5%(wt)甘油三酯组(对照组),20%(wt)甘油三酯组(TG组)和20%(wt)1,3—甘油二酯组(DG组)。大鼠喂养10W,每天记录进食量,每周称体重,于第10周末处死大鼠,称体重和内脏脂肪,计算脂体比,测定血糖、血脂和各种激素水平,RT-PCR的方法检测大鼠下丘脑神经肽Y mRNA表达水平。结果:高甘油二酯组与高甘油三酯组比较,改善体重的增加及内脏脂肪的积累,降低大鼠血糖、血甘油三酯(TG)、胰岛素水平,同时降低大鼠下丘脑神经肽Y mRNA的表达水平。结论:甘油二酯降低脂肪积累和改善血脂水平的可能机制是改变下丘脑有关控制食欲的基因表达,进而影响了脂肪代谢的平衡。

引用

页码：541 / 543+547 +547

页数：4

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