前列腺素E2及其受体对炎性痛调制的研究进展

被引：34

作者：

黄冰晴

王兵丽

机构：

[1] 闽南师范大学生物科学与技术学院

来源：

闽南师范大学学报(自然科学版) | 2017年 / 30卷 / 02期

关键词：

前列腺素类E2; 前列腺素类E2受体; 微粒体前列腺素E合酶-1; 炎性痛;

D O I：

10.16007/j.cnki.issn2095-7122.2017.02.010

中图分类号：

R402 [];

学科分类号：

摘要：

前列腺素类E2(prostaglandin E2,PGE2)是一种重要的脂质代谢产物,它参与调节多种生理和病理过程,包括炎性疼痛.研究PGE2在疼痛中所起到的作用及其机制有利于阐明痛觉生理和发现疼痛治疗的新手段.目前研究表明,PGE2在中枢可以通过EP受体引起神经递质谷氨酸等的释放,从而导致中枢敏感化;在外周参与伤害性感受器的活化,促进伤害性信息的传递.PGE2及其受体可以作为开发镇痛药物的新靶点.

引用

页码：65 / 70

页数：6

共 21 条

[1]

微粒体前列腺素E2合成酶-1抑制剂研究进展 [J].

张畅斌 ;

陆茵 ;

姜廷良 .

现代药物与临床, 2010, 25 (01) :11-14

[2]

...晨报.1916,

[3]

Pharmacokinetics and estimated bioavailability of grapiprant; a novel selective prostaglandin E<sub>2</sub> receptor antagonist; after oral administration in fasted and fed dogs.[J].B ?ebkowska-Wieruszewska;G Barsotti;A Lisowski;A Gazzano;H Owen;M Giorgi.New Zealand Veterinary Journal.2017, 1

[4]

Janus kinase 2 activation participates in prostaglandin E2-induced hyperalgesia.[J].André Schwambach Vieira;Dionéia Araldi;Elayne Vieira Dias;Filipe César do Prado;Claudia Herrera Tambeli;Carlos Amilcar Parada.Life Sciences.2016,

[5]

Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors.[J].Bruno St-Jacques;Weiya Ma.Experimental Neurology.2014,

[6]

Increased Interleukin-1α and Prostaglandin E2 Expression in the Spinal Cord at 1 Day After Painful Facet Joint Injury: Evidence of Early Spinal Inflammation.[J].Jeffrey V. Kras;Ling Dong;Beth A. Winkelstein.Spine.2014, 3

[7]

Characterization of a new mPGES-1 inhibitor in rat models of inflammation.[J].Patrick Leclerc;Sven-Christian Pawelzik;Helena Idborg;Linda Spahiu;Charlotte Larsson;Patric Stenberg;Marina Korotkova;Per-Johan Jakobsson.Prostaglandins and Other Lipid Mediators.2013,

[8]

ChemInform Abstract: Fragment‐Based Discovery of Novel and Selective mPGES‐1 Inhibitors. Part 1. Identification of Sulfonamido‐1;2;3‐triazole‐4;5‐dicarboxylic Acid..[J].Kijae Lee;Van Chung Pham;Min Ji Choi;Kyung Ju Kim;Kyung‐Tae Lee;Seong‐Gu Han;Yeon Gyu Yu;Jae Yeol Lee.ChemInform.2013, 21

[9]

Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs [J].

Kawada, Noritaka ;

Moriyama, Toshiki ;

Kitamura, Harumi ;

Yamamoto, Ryohei ;

Furumatsu, Yoshiyuki ;

Matsui, Isao ;

Takabatake, Yoshitsugu ;

Nagasawa, Yasuyuki ;

Imai, Enyu ;

Wilcox, Christopher S. ;

Rakugi, Hiromi ;

Isaka, Yoshitaka .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2012, 16 (01) :25-29

[10]

Analgesic Effects of Prostaglandin E2 Receptor Subtype EP1 Receptor Antagonist: Experimental Study of Application of Nucleus Pulposus.[J].Miho Sekiguchi;Kenichi Otoshi;Shin-ichi Kikuchi;Shin-ichi Konno.Spine.2011, 22

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