缺血性卒中后血浆超敏C-反应蛋白和白介素-6的早期动态变化与临床表现的关系探讨

被引：10

作者：

马越涛

刘丽萍

王拥军

机构：

[1] 首都医科大学附属北京天坛医院神经内科

来源：

中国卒中杂志 | 2011年 / 6卷 / 04期

关键词：

脑梗死; C反应蛋白质; 白细胞介素6;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的观察急性缺血性卒中患者发病后早期血浆超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)及白介素-6(interleukin-6,IL-6)水平的动态变化规律,探讨其与卒中患者临床表现及预后的关系。方法连续入选急性缺血性卒中患者47例,正常对照组40例,比较卒中组发病后系列时间点血浆hs-CRP和IL-6水平与正常对照组之间的差异,分析其动态变化规律;按照基线美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分将患者分为轻型组(n=15)和重型组(n=32),比较两组血浆hs-CRP和IL-6水平;并比较不同临床预后患者血浆hs-CRP和IL-6水平的差异。结果卒中组发病3h时血浆hs-CRP较对照组差异无统计学意义,6h、12h、24h、48h、3d及7d血浆hs-CRP较对照组明显升高(均P≤0.01)。卒中组各时间点血浆IL-6水平均高于正常对照组(均P<0.01)。重型组血浆hs-CRP水平在12h、24h、48h、3d及7d时水平均高于轻型组(P=0.046,0.012,0.030,0.007,0.041);重型组血浆IL-6水平在12h、24h、48h、3d及7d时水平均高于轻型组(P=0.002,0.001,0.006,0.026,0.043)。不同预后组之间血浆hs-CRP和IL-6水平差异不明显。结论急性缺血性卒中患者血浆hs-CRP和IL-6水平升高,且与临床严重程度有关。

引用

页码：268 / 274

页数：7

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