高效液相色谱-串联质谱法（HPLC-MS~n）分析生物样品时的基质效应研究

被引：32

作者：

贾彦波

王清清

宋海峰

机构：

[1] 军事医学科学院放射与辐射医学研究所药理毒理研究室

来源：

军事医学 | 2011年 / 35卷 / 02期

关键词：

基质效应; 高效液相色谱-串联质谱法; 定量分析; 药代动力学;

D O I：

暂无

中图分类号：

O657.63 [质谱分析]; Q503 [生物化学技术];

学科分类号：

070302 [分析化学]; 070307 [化学生物学];

摘要：

高效液相色谱-串联质谱法(HPLC-MSn)是一种高灵敏和高选择性定量分析方法,然而进行HPLC-MSn分析时基质效应会影响分析方法的特异性、精密度和准确度。本文结合国内外文献,对分析过程中基质效应产生原因,评价基质效应的方法以及如何降低或消除基质效应进行了综述。

引用

页码：149 / 152

页数：4

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