骨钙素介导的骨内分泌系统

被引：45

作者：

王春玉 ^{[1
]}

龙丰云 ^{[2
]}

陈香 ^{[1
]}

余希杰 ^{[1
]}

机构：

[1] 四川大学华西医院内分泌与代谢病研究室

[2] 四川省乐山市犍为县妇幼保健院

来源：

中华骨质疏松和骨矿盐疾病杂志 | 2013年 / 6卷 / 03期

基金：

教育部留学回国人员科研启动基金;

关键词：

骨内分泌; 骨钙素; 低羧化骨钙素; 反馈;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨为新型的内分泌器官,具有内分泌功能。目前发现骨分泌2种激素:成纤维细胞因子23(FGF23)和骨钙素(OCN)。成骨细胞/骨细胞分泌的FGF23主要作用于肾脏调节磷代谢;成骨细胞/骨细胞分泌的OCN存储于骨基质,经破骨细胞的吸收脱羧后以低羧化形式(ucOCN)释放入血,最终作用于胰岛β细胞、脂肪细胞和睾丸间质细胞。ucOCN和靶器官之间形成反馈节环,调控能量代谢和雄性生殖功能。

引用

收藏

页码：196 / 202

页数：7

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