低分子肝素皮下注射治疗轻-中度活动性溃疡性结肠炎的疗效评价

被引：22

作者：

宋军民

李卉

李岩

机构：

[1] 中国医科大学附属盛京医院消化内科

来源：

胃肠病学和肝病学杂志 | 2013年 / 22卷 / 10期

关键词：

溃疡性结肠炎; 低分子肝素; 疗效评价; 凝血; 抗凝治疗;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

目的评价低分子肝素(low-molecular-weight-heparin,LMWH)皮下注射辅助治疗轻-中度活动性溃疡性结肠炎(UC)的疗效。方法 48例轻-中度活动性UC患者随机分成2组(每组24例),分别接受5-氨基水杨酸和5-氨基水杨酸+低分子肝素钙皮下注射治疗,所有患者治疗前后均进行临床活动指数(CAI)、炎症指标(CRP、ESR、FIB)、凝血指标(PT、APTT、TT、D-二聚体和血小板计数)和内镜指数(EI)评价,并比较治疗后的改善情况。结果治疗后5-氨基水杨酸+低分子肝素钙组的CRP、D-二聚体较5-氨基水杨酸组显著下降(P<0.05),但CAI、EI和其他指标与5-氨基水杨酸组相比差异无统计学意义(P>0.05)。结论低分子肝素皮下注射能改善轻-中度活动性UC的部分炎症和凝血指标,但对临床症状和内镜下表现无显著改善作用。

引用

页码：997 / 1000

页数：4

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