糖尿病的抗氧化治疗及问题

被引:8
作者
贺凯 [1 ]
杨勇 [1 ]
李学刚 [2 ]
机构
[1] 怀化医学高等专科学校生物医学研究中心
[2] 西南大学药学院
关键词
D O I
10.13820/j.cnki.gdyx.2013.04.028
中图分类号
R587.1 [糖尿病];
学科分类号
100201 [内科学];
摘要
<正>随着人口老龄化的程度不断加深,研究表明到2030年全球将有4.39亿人患糖尿病(diabetes mellitus,DM)[1]。因此,阐明DM的治病机制及探索有效预防和治疗DM的措施刻不容缓。NISHIKAWA等[2]首先发现,通过使细胞中线粒体产的过氧化物含量正常化可以预防3个代谢通路所引起的高血糖损伤,它们均被认为是与DM发生有密切联系的,包括高血糖诱导的蛋白激酶C活化通路、糖基化末端产物的
引用
收藏
页码:640 / 643
页数:4
相关论文
共 9 条
[1]
坎地沙坦不同治疗时机对2型糖尿病KK/Ta小鼠肾脏硝化氧化应激的影响 [J].
范秋灵 ;
蒲实 ;
李卅立 ;
董雪竹 ;
张丛笑 ;
杨刚 ;
姜奕 ;
王力宁 .
中国中西医结合肾病杂志, 2012, (05) :398-401+477
[2]
A mitochondria-based method for the determination of antioxidant activities using 2′,7′-dichlorofluorescin diacetate oxidation [J].
He, Kai ;
Li, Xuegang ;
Ye, Xiaoli ;
Yuan, Lujiang ;
Li, Xiaoduo ;
Chen, Xin ;
Deng, Yafei .
FOOD RESEARCH INTERNATIONAL, 2012, 48 (02) :454-461
[3]
Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population.[J].Jhoti Somanah;Okezie I. Aruoma;Teeluck K. Gunness;Sudhir Kowelssur;Venkatesh Dambala;Fatima Murad;Kreshna Googoolye;Diana Daus;Joseph Indelicato;Emmanuel Bourdon;Theeshan Bahorun.Preventive Medicine.2012,
[4]
Vitamin D and type 2 diabetes mellitus: Where do we stand? [J].
Cavalier, E. ;
Delanaye, P. ;
Souberbielle, J. -C. ;
Radermecker, R. -P. .
DIABETES & METABOLISM, 2011, 37 (04) :265-272
[5]
Serum resistance to singlet oxygen in patients with diabetes mellitus in comparison to healthy donors [J].
Lhommeau, Isabelle ;
Douillard, Samuel ;
Bigot, Edith ;
Benoit, Isabelle ;
Krempf, Michel ;
Patrice, Thierry .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2011, 60 (09) :1340-1348
[6]
Erythrocytic enzymes and antioxidant status in people with type 2 diabetes: Beneficial effect of Syzygium cumini leaf extract in vitro [J].
De Bona, Karine Santos ;
Belle, Luziane Potrich ;
Rodrigues Bittencourt, Paula Eliete ;
Bonfanti, Gabriela ;
Cargnelluti, Lariane Oliveira ;
Pimentel, Victor Camera ;
Ruviaro, Amanda Roggia ;
Chitolina Schetinger, Maria Rosa ;
Emanuelli, Tatiana ;
Moretto, Maria Beatriz .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2011, 94 (01) :84-90
[7]
Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice [J].
Matsumoto, Masakazu ;
Tanimoto, Mitsuo ;
Gohda, Tomohito ;
Aoki, Tatsuya ;
Murakoshi, Maki ;
Yamada, Kaorl ;
Yamazaki, Takahiko ;
Kaneko, Shigeru ;
Horikoshi, Satoshi ;
Tomino, Yasuhiko .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2008, 57 (05) :691-697
[8]
Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells [J].
Drel, VR ;
Pacher, P ;
Stevens, MJ ;
Obrosova, IG .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (08) :1454-1465
[9]
Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: Relationship to mitochondrial antioxidant capacity.[J]..Life Sciences.1999, 10