网络药理学研究中的网络构建技术

被引:10
作者
周文霞
王同兴
程肖蕊
韩露
张永祥
机构
[1] 军事医学科学院毒物药物研究所,抗毒药物和毒理学国家重点实验室
关键词
网络药理学; 阿尔茨海默病; 网络构建; 药物组网络; 疾病组网络; 分子相互作用组网络; 复杂网络可视化;
D O I
10.13220/j.cnki.jipr.2016.05.001
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
网络构建技术是网络药理学研究中的基础技术,也是核心技术。通过整合来源于实验、数据库和计算预测等的包含药物、疾病及生物分子等在内的用于网络构建的相关数据,采用复杂网络构建技术进行药物作用相关、疾病相关和生物分子相关的网络模型构建,尤其对于以阿尔茨海默病为代表的复杂疾病分子网络的构建,为进一步重要靶标的辨识、发病机制和药物作用机制的阐释、指导药物开发,以及药物重定位等打下基础。本文就网络药理学研究相关的药物组网络、疾病组网络和分子相互作用组网络等的构建及其可视化技术进行综述。
引用
收藏
页码:797 / 812
页数:16
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