基因多态性对抗抑郁药物疗效的影响

被引:3
作者
闵文蛟 [1 ,2 ]
毛文君 [1 ]
陶立 [3 ]
孙学礼 [2 ]
机构
[1] 成都市第四人民医院临床心理科
[2] 四川大学华西医院心理卫生中心
[3] 四川省安岳县康复医院精神科
关键词
抑郁症; 基因; 多态性; 疗效;
D O I
暂无
中图分类号
R971 [神经系统药物];
学科分类号
100115 [医学神经生物学];
摘要
抑郁症是临床常见精神疾病之一,疾病负担重,而有相当部分患者对抗抑郁药物治疗无效或效果较差。目前研究发现,抑郁症患者对药物治疗表现出遗传异质性,一些基因位点,如五羟色胺转运蛋白基因、五羟色胺2A受体、色氨酸羟化酶基因等,可能与抗抑郁药物疗效相关。本文总结了抗抑郁药物疗效相关基因多态性的研究现状及进展,对这些基因的深入阐释有助于在将来研发更为有效的药物,为抑郁症患者提供遗传背景个体化的治疗。
引用
收藏
页码:1275 / 1279
页数:5
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