水通道蛋白1与羊水量的关系

被引：3

作者：

韩平

佘广彤

孙丽洲

机构：

[1] 南京医科大学第一附属医院妇产科

来源：

江苏医药 | 2010年 / 36卷 / 13期

关键词：

水通道蛋白1; 羊水;

D O I：

10.19460/j.cnki.0253-3685.2010.13.010

中图分类号：

R714.2 [病理妊娠（异常妊娠）];

学科分类号：

摘要：

目的研究水通道蛋白1(AQP1)与羊水量关系。方法运用免疫组织化学法分别检测20例羊水过少(A组)、17例羊水过多(B组)、22例羊水正常(C组)的胎盘、胎膜组织中AQP1的表达;同时每组随机抽取10例用免疫印迹法分别检测胎盘、胎膜组织中AQP1的蛋白表达量。结果 AQP1主要在羊膜上皮细胞、平滑绒毛膜细胞滋养细胞、胎盘合体滋养细胞和血管内皮细胞的胞浆中表达。免疫组织化学法结果显示,AQP1在A、B和C组胎膜的表达强度分别为(5.82±1.33)、(7.94±1.85)和(6.75±1.25)(P<0.01);免疫印迹法结果显示,AQP1在胎膜的表达强度分别为(13.35±3.33)、(19.51±2.84)和(16.21±2.45)(P<0.01)。胎膜AQP1蛋白表达量随着羊水量的增加相应上调。结论胎膜中AQP1的表达随着羊水量的增多而增加。AQP1在胎膜的上调节可能促进了羊水的跨膜转运。

引用

页码：1517 / 1519

页数：3

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