骨质疏松相关信号通路研究进展

被引：47

作者：

查小云

胡予

机构：

[1] 复旦大学附属中山医院老年科

来源：

中国骨质疏松杂志 | 2014年 / 20卷 / 02期

关键词：

骨质疏松; 信号通路; RANKL/RANK/OPG信号通路; Wnt/β-catenin信号通路; PTH信号通路; PPAR-γ信号通路;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨代谢过程包括骨形成及骨吸收,当两者间的平衡被打破后便会出现骨硬化或者骨量减少甚至骨质疏松,其具体的分子调节通路不明。现代研究表明,在骨代谢过程中至少存在RANKL/RANK/OPG信号通路、Wnt/β-catenin信号通路、PTH信号通路、PPAR-γ信号通路等,各个通路间还存在交叉。通过分子信号通路,可有效促进骨代谢研究,并开发具有治疗骨质疏松的新药。

引用

页码：205 / 209

页数：5

共 18 条

[1]

The skeletal effects of thiazolidinedione and metformin on insulin-resistant mice [J].

Wang, Chun ;

Li, Hong ;

Chen, Sheng-Guang ;

He, Jin-Wei ;

Sheng, Chun-Jun ;

Cheng, Xiao-Yun ;

Qu, Shen ;

Wang, Ke-Sheng ;

Lu, Mei-Ling ;

Yu, Yong-Chun .

JOURNAL OF BONE AND MINERAL METABOLISM, 2012, 30 (06) :630-637

[2]

c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton [J].

Izawa, Takashi ;

Zou, Wei ;

Chappel, Jean C. ;

Ashley, Jason W. ;

Feng, Xu ;

Teitelbaum, Steven L. .

MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (14) :2943-2953

[3]

Update on Bone Anabolics in Osteoporosis Treatment: Rationale, Current Status, and Perspectives [J].

Baron, Roland ;

Hesse, Eric .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (02) :311-325

[4]

Genetics of Osteoporosis [J].

Ralston, Stuart H. ;

Uitterlinden, Andre G. .

ENDOCRINE REVIEWS, 2010, 31 (05) :629-662

[5]

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation [J].

Guo, Jun ;

Liu, Minlin ;

Yang, Dehong ;

Bouxsein, Mary L. ;

Saito, Hiroaki ;

Galvin, R. J. Sells ;

Kuhstoss, Stuart A. ;

Thomas, Clare C. ;

Schipani, Ernestina ;

Baron, Roland ;

Bringhurst, F. Richard ;

Kronenberg, Henry M. .

CELL METABOLISM, 2010, 11 (02) :161-171

[6]

Mechanisms Underlying Catabolic and Anabolic Functions of Parathyroid Hormone on Bone by Combination of Culture Systems of Mouse Cells [J].

Shinoda, Yusuke ;

Kawaguchi, Hiroshi ;

Higashikawa, Akiro ;

Hirata, Makoto ;

Miura, Toshiki ;

Saito, Taku ;

Nakamura, Kozo ;

Chung, Ung-il ;

Ogata, Naoshi .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 109 (04) :755-763

[7]

Bone Density Ligand; Sclerostin; Directly Interacts With LRP5 but Not LRP5.[J].Debra L Ellies;Beth Viviano;John McCarthy;Jean‐Philippe Rey;Nobue Itasaki;Scott Saunders;Robb Krumlauf PhD.Journal of Bone and Mineral Research.2006, 11

[8]

Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis [J].