雄激素过多在多囊卵巢综合征发生发展中的作用

被引:18
作者
丁涛 [1 ]
郑艳华 [1 ]
谢军 [1 ]
马红霞 [2 ]
吴效科 [3 ]
机构
[1] 广州医学院
[2] 广州医学院第一附属医院中医科
[3] 黑龙江中医药大学第一附属医院妇产科
关键词
雄激素类; 多囊卵巢综合征; 卵巢; 无排卵; 胰岛素抗药性;
D O I
暂无
中图分类号
R711.75 [卵巢疾病];
学科分类号
100211 [妇产科学];
摘要
目前多囊卵巢综合征(PCOS)的病因仍不十分明确,尚未发现其确切致病基因,不少研究表明雄激素过多与PCOS的发生密切相关,可能是促进其发生发展的重要因素。现普遍认为高雄激素血症是PCOS发病的根本原因之一,表现为特异性症状和并发症。然而,卵巢多小卵泡、不排卵和胰岛素抵抗的生育期妇女雄激素水平较高,使症状与并发症恶化,这就导致高雄激素血症的恶性循环。就高雄激素血症导致PCOS进行综述。
引用
收藏
页码:119 / 124
页数:6
相关论文
共 17 条
[1]
Androgen levels, insulin sensitivity, and early insulin response in women with polycystic ovary syndrome: a long-term follow-up study [J].
Hudecova, Miriam ;
Holte, Jan ;
Moby, Lena ;
Olovsson, Matts ;
Stridsberg, Mats ;
Larsson, Anders ;
Berglund, Lars ;
Berne, Christian ;
Poromaa, Inger Sundstrom .
FERTILITY AND STERILITY, 2011, 95 (03) :1146-1148
[2]
Developmental Programming: Impact of Excess Prenatal Testosterone on Intrauterine Fetal Endocrine Milieu and Growth in Sheep<sup>1</sup>.[J].Almudena Veiga-Lopez;Teresa L. Steckler;David H. Abbott;Kathleen B. Welch;Puliyur S. MohanKumar;David J. Phillips;Kent Refsal;Vasantha Padmanabhan.Biology of Reproduction.2011, 1
[3]
Ovarian and adipose tissue dysfunction in polycystic ovary syndrome: report of the 4th special scientific meeting of the Androgen Excess and PCOS Society [J].
Yildiz, Bulent O. ;
Azziz, Ricardo .
FERTILITY AND STERILITY, 2010, 94 (02) :690-693
[4]
Effect of finasteride on ovulation induction in nonresponder (hyperandrogenic) polycystic ovary syndrome (PCOS) women [J].
Tartagni, Massimo ;
Cicinelli, Ettore ;
De Pergola, Giovanni ;
Lavopa, Cristina ;
Di Naro, Edoardo ;
De Salvia, Maria Antonietta ;
Loverro, Giuseppe .
FERTILITY AND STERILITY, 2010, 94 (01) :247-249
[5]
Exogenous androstenedione induces formation of follicular cysts and premature luteinization of granulosa cells in the ovary [J].
Okutsu, Yuki ;
Itoh, Masanori T. ;
Takahashi, Noriyuki ;
Ishizuka, Bunpei .
FERTILITY AND STERILITY, 2010, 93 (03) :927-935
[6]
Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: A comparison with gonadally intact males [J].
Feng, Yi ;
Weijdegard, Birgitta ;
Wang, Tienpei ;
Egecioglu, Emil ;
Fernandez-Rodriguez, Julia ;
Huhtaniemi, Ilpo ;
Stener-Victorin, Elisabet ;
Billig, Hakan ;
Shao, Ruijin .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 321 (02) :161-174
[7]
The Relationship between Maternal and Umbilical Cord Androgen Levels and Polycystic Ovary Syndrome in Adolescence: A Prospective Cohort Study [J].
Hickey, M. ;
Sloboda, D. M. ;
Atkinson, H. C. ;
Doherty, D. A. ;
Franks, S. ;
Norman, R. J. ;
Newnham, J. P. ;
Hart, R. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (10) :3714-3720
[8]
Fetal androgen excess provides a developmental origin for polycystic ovary syndrome.[J].Abbott;Dumesic.Expert Review of Obstetrics & Gynecology.2009, 1
[9]
Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys<sup>1</sup>.[J].David H. Abbott;Deborah K. Barnett;Jon E. Levine;Vasantha Padmanabhan;Daniel A. Dumesic;Steve Jacoris;Alice F. Tarantal.Biology of Reproduction.2008, 1
[10]
Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart; Lung; and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation.[J].Leslee J. Shaw;C Noel Bairey Merz;Ricardo Azziz;Frank Z. Stanczyk;George Sopko;Glenn D. Braunstein;Sheryl F. Kelsey;Kevin E. Kip;Rhonda M. Cooper-DeHoff;B Delia Johnson;Viola Vaccarino;Steven E. Reis;Vera B