雷公藤红素药理作用分子靶点的研究进展

被引：15

作者：

丁海鹏 ^{[1
]}

李相鹏 ^{[1
]}

张伟 ^{[2
]}

丁宁 ^{[2
]}

王鹏 ^{[1
]}

李国强 ^{[1
]}

李英霞 ^{[2
]}

机构：

[1] 中国海洋大学医药学院海洋药物教育部重点实验室山东省海洋药物重点实验室

[2] 复旦大学药学院药物化学系

来源：

中国药理学与毒理学杂志 | 2012年 / 26卷 / 04期

关键词：

雷公藤红素; 药理作用; 分子靶点; NF-κB; 热休克蛋白90; 细胞分裂周期蛋白; P23;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

雷公藤红素是从传统中药雷公藤中提取分离得到的一种醌甲基三萜,具有抗炎、免疫抑制及抗肿瘤等药理活性。雷公藤红素几个特殊的分子靶点大多会抑制IKK-NF-κB信号通路,包括:①抑制IKKα/β激酶;②失活热休克蛋白90的分子伴侣蛋白细胞分裂周期蛋白37及P23;③抑制蛋白酶体的功能;④激活热激因子1诱导热休克蛋白反应;⑤影响肿瘤细胞的增殖;⑥影响细胞凋亡;⑦影响丝裂原活化蛋白激酶;⑧影响Akt/mTOR信号级联;⑨影响血管生成和转移;⑩抗炎作用。本文对其药理作用分子靶点研究进展做一综述。

引用

页码：570 / 576

页数：7

共 19 条

[1]

雷公藤红素对U937细胞Notch 1、NF-κB信号蛋白通路的调控作用.[J].王晓南;吴青;杨旭;张连生;吴一品;卢聪;.癌症.2010, 04

[2]

Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways [J].

Mou, Haibo ;

Zheng, Yi ;

Zhao, Peng ;

Bao, Hanying ;

Fang, Weijia ;

Xu, Nong .

TOXICOLOGY IN VITRO, 2011, 25 (05) :1027-1032

[3]

Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells [J].

Seo, Won Yong ;

Ju, Sung Mi ;

Song, Ha Yong ;

Goh, Ah Ra ;

Jun, Jong-Gab ;

Kang, Young-Hee ;

Choi, Soo Young ;

Park, Jinseu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 398 (01) :140-145

[4]

Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L [J].

Zhu, Hong ;

Liu, Xiao-Wen ;

Ding, Wan-Jing ;

Xu, Dan-Qing ;

Zhao, Yu-Chen ;

Lu, Wei ;

He, Qiao-Jun ;

Yang, Bo .

CANCER LETTERS, 2010, 297 (02) :155-164

[5]

Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol [J].

Zhu, Hong ;

Ding, Wan-Jing ;

Wu, Rui ;

Weng, Qin-Jie ;

Lou, Jian-Shu ;

Jin, Rong-Jia ;

Lu, Wei ;

Yang, Bo ;

He, Qiao-Jun .

CANCER INVESTIGATION, 2010, 28 (01) :23-32

[6]

Celastrol Suppresses Morphological and Transcriptional Responses in Microglial Cells Upon Stimulation with Double-Stranded RNA [J].

Nakamichi, Kazuo ;

Kitani, Hiroshi ;

Takayama-Ito, Mutsuyo ;

Morimoto, Kinjiro ;

Kurane, Ichiro ;

Saijo, Masayuki .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2010, 120 (04) :252-257

[7]

Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells [J].

Davenport, Andrew ;

Frezza, Michael ;

Shen, Min ;

Ge, Yubin ;

Huo, Congde ;

Chan, Tak Hang ;

Dou, Q. Ping .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2010, 25 (03) :465-470

[8]

Celastrol causes apoptosis and cell cycle arrest in rat glioma cells [J].

Ge, Pengfei ;

Ji, Xunming ;

Ding, Yuchuan ;

Wang, Xiaofei ;

Fu, Shuangliin ;

Meng, Fankai ;

Jin, Xin ;

Ling, Feng ;

Luo, Yinan .

NEUROLOGICAL RESEARCH, 2010, 32 (01) :94-100

[9]

Celastrol, a Triterpene Extracted From Tripterygium wilfordii Hook F, Inhibits Platelet Activation [J].

Hu, Houyuan ;

Straub, Andreas ;

Tian, Zhuo ;

Bassler, Nicole ;

Cheng, Jun ;

Peter, Karlheinz .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2009, 54 (03) :240-245

[10]

Celastrol binds to ERK and inhibits FcεRI signaling to exert an anti-allergic effect.[J].Youngmi Kim;Kyungjong Kim;Hansoo Lee;Sanghwa Han;Yun-Sil Lee;Jongseon Choe;Young-Myeong Kim;Jang-Hee Hahn;Jai Youl Ro;Dooil Jeoung.European Journal of Pharmacology.2009, 1

← 1 2 →