Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol

被引：68

作者：

Zhu, Hong ^{[1
]}

Ding, Wan-Jing ^{[1
]}

Wu, Rui ^{[1
]}

Weng, Qin-Jie ^{[1
]}

Lou, Jian-Shu ^{[1
]}

Jin, Rong-Jia ^{[1
]}

Lu, Wei ^{[2
,3
]}

Yang, Bo ^{[1
]}

He, Qiao-Jun ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol & Toxicol, Hangzhou 310058, Zhejiang, Peoples R China

[2] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

[3] E China Normal Univ, Inst Med Chem, Shanghai 200062, Peoples R China

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 01期

关键词：

TRAIL/APO-2L; Celastrol; Combination therapy; Combination index; Apoptosis; Anti-cancer; TRAIL-INDUCED APOPTOSIS; LIGAND (TRAIL)-INDUCED APOPTOSIS; CANCER-CELL-LINE; ANTITUMOR-ACTIVITY; DEATH RECEPTORS; DECOY RECEPTORS; TUMOR-CELLS; CHEMOTHERAPY; MECHANISMS; RESISTANCE;

D O I：

10.3109/07357900903095664

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The present study demonstrates that the combination of TRAIL/APO-2L and celastrol exerts strong synergistic antiproliferative effect against human cancer cells including ovary cancer OVCAR-8, colon cancer SW620, and lung cancer 95-D, with the combination indices below 0.8. Moreover, the in vivo antitumor efficacy of TRAIL/APO-2L was dramatically increased by celastrol. These enhanced anticancer activities were accompanied by the prompt onset of caspase-mediated apoptosis. Taken together, our data firstly demonstrate the synergistic anticancer capabilities achieved by combining TRAIL-APO-2L and celastrol, and moreover, open new opportunities to enhance the effectiveness of future treatment regimens using TRAIL/APO-2L.

引用

页码：23 / 32

页数：10

共 28 条

[1]

Safety and antitumor activity of recombinant soluble Apo2 ligand [J].