Skp2在恶性肿瘤的发生及治疗中的研究进展

被引：5

作者：

孙雅静

机构：

[1] 天津市第五中心医院病理科

来源：

国际免疫学杂志 | 2018年 / 41卷 / 05期

关键词：

细胞S期激酶相关蛋白2; 细胞周期; 肿瘤; 治疗;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

肿瘤发生的根本原因是细胞周期调控紊乱, 细胞S期激酶相关蛋白2(S-phase associated kinase protein 2, Skp2)是新近认识的细胞周期调控的蛋白之一。在多种肿瘤中高表达, 例如:直肠癌, 肺癌, 胶质瘤, 前列腺癌等;并影响患者预后。Skp2作为肿瘤基因治疗的新的靶点, 抑制其表达能有效的控制肿瘤的发展, 提高患者的预后, 现就Skp2的结构、功能和与肿瘤的相关性进行综述。

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