Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

被引：23

作者：

Wu, Lichuan ^{[1
]}

Wang, Guizhen ^{[2
]}

Wei, Jinrui ^{[3
]}

Huang, Na ^{[4
]}

Zhang, Sen ^{[1
]}

Yang, Fangfang ^{[1
]}

Li, Ming ^{[5
]}

Zhou, Guangbiao ^{[2
]}

Wang, Lisheng ^{[1
]}

机构：

[1] Guangxi Univ, Sch Chem & Chem Engn, Nanning, Guangxi, Peoples R China

[2] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China

[3] Guangxi Univ Chinese Med, Guangxi Sci Res Ctr Tradit Chinese Med, Nanning, Guangxi, Peoples R China

[4] Guangxi Med Univ, Affiliated Tumour Hosp, Nanning, Guangxi, Peoples R China

[5] Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 07期

基金：

国家杰出青年科学基金; 中国博士后科学基金; 中国国家自然科学基金;

关键词：

lung cancer; matrine derivative; Skp2; proliferation; migration; IN-VITRO; TARGET; P27; DEGRADATION; P27(KIP1); APOPTOSIS; PATHWAY; PROTEIN; CYCLE; UBIQUITINATION;

D O I：

10.18632/oncotarget.14329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dosedependent manner. The findings indicate that YF-18 bears therapeutic potentials for

引用

页码：11729 / 11738

页数：10

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