氯吡格雷抵抗

被引：1

作者：

杨帆

赖沙毅

机构：

[1] 广西医科大学第四附属医院柳州市工人医院心内科

来源：

新医学 | 2005年 / 11期

关键词：

氯吡格雷抵抗; 急性冠状动脉综合征; 心绞痛; 冠状动脉内支架植入术;

D O I：

暂无

中图分类号：

R973 [血液和造血系统药物];

学科分类号：

1007 ;

摘要：

氯吡格雷是临床常用的抗血小板药物,现发现部分患者存在氯吡格雷抵抗,笔者对氯吡格雷抵抗的定义、发生率及可能发生的机制进行分析,探讨氯吡格雷抵抗的检测和解决方法,为临床识别和预防氯吡格雷抵抗提供参考。

引用

页码：666 / 667

页数：2

共 14 条

[1]

Theinvivopharmacologicalprofile ofCS747,anovelantiplateletagentwithplateletADPreceptorantagonist properties. SugidachiA,AsaiF,OgawaT,etal. British Journal of Pharmacology . 2000

[2]

Impactofanginaclassoninhibition ofplateletaggregationfollowingclopidogrelloadinginpatientsundergoing coronaryintervention:doweneedmoreaggressivedosingregimensinun stableangina. SofferD,MoussaI,HarjaiKJ,etal. CatheterCardiovascInterv . 2003

[3]

Lackofadverseclopidogrel atorv astatinclinicalinteractionfromsecondaryanalysisofarandomized,place bo controlledclopidogreltrial. SawJ,SteinhublSR,BergerPB,etal. Circulation . 2003

[4]

Atorvastatinreducestheability ofclopidogreltoinhibitplateletaggregation:anewdrug drug interaction. LauWC,WaskellLA,WatkinsPB,etal. Circulation . 2003

[5]

Themetabolismofclopidogreliscatalyzedby humancytochromeP4503Aandisinhibitedbyatorvastatin. ClarkeTA,WaskellLA. Drug Metabolism and Disposition . 2003

[6]

Prevalenceofclopidogrelnon respond ersamongpatientswithstableanginapectorisscheduledforelectivecoro narystentplacement. MullerI,BestaF,SchulzC,etal. Thrombosis and Haemostasis . 2003

[7]

Plateletfunctionassays. RandML,LeungR,PackhamMA. Transfus ApheresisSci . 2003

[8]

Clopidogrelforcoronarystenting:responsevariability,drugresistance,andtheeffectofpretreatmentplatelet reactivity. GurbelPA,BlidenKP,HiattBL,etal. Circulation . 2003

[9]

Clopidogrelresistanceisasso ciatedwithincreasedriskofrecurrentatherothromboticeventsinpatients withacutemyocardialinfarction. MatetzkyS,ShenkmanB,GuettaV,etal. Circulation . 2004

[10]

TheP2Y12receptorasatherapeutictargetincardiovasculardis ease. StoreyRF. Platelets . 2001

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