MicroRNA在多囊卵巢综合征中的表达及作用

被引：10

作者：

郑赛花

李雪莲

机构：

[1] 复旦大学附属妇产科医院妇科上海市女性生殖内分泌相关疾病重点实验室

来源：

国际生殖健康/计划生育杂志 | 2016年 / 35卷 / 02期

关键词：

微RNAs; 多囊卵巢综合征; 胰岛素抗药性; 性腺甾类激素;

D O I：

暂无

中图分类号：

R711.75 [卵巢疾病];

学科分类号：

100211 [妇产科学];

摘要：

非编码微小RNAs(microRNAs,miRNAs)主要在转录后水平上调控基因表达,异常miRNA表达与胰岛素抵抗、糖尿病、炎症及各种癌症形成有关。多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清及卵泡液中miRNAs表达谱存在差异,其异常的miRNAs表达能够通过影响基因转录后水平,参与PCOS的发生发展。综述miR-93、miR-222、miR-92a/b、miR-224、miR-320、miR-9、miR-483-5p、miR-513a-3p、miR-24、miR-133b、miR-26b和miR-378在PCOS患者的胰岛素抵抗、性激素合成和分泌、颗粒细胞增生、卵泡发育异常及排卵障碍中的作用,探讨miRNA在PCOS发病机制中的作用。

引用

收藏

页码：146 / 150

页数：5

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