Regulatory role of microRNAs in ovarian function

被引：187

作者：

Imbar, Tal ^{[1
,2
]}

Eisenberg, Iris ^{[2
]}

机构：

[1] Hadassah Hebrew Univ, Med Ctr, IVF Unit, IL-91240 Jerusalem, Israel

[2] Hadassah Hebrew Univ, Med Ctr, Magda & Richard Hoffman Ctr Human Placenta Res, Dept Obstet & Gynecol, IL-91240 Jerusalem, Israel

来源：

FERTILITY AND STERILITY | 2014年 / 101卷 / 06期

基金：

以色列科学基金会;

关键词：

microRNA; ovulation; corpus luteum; PCOS; POF; serum biomarkers; DIFFERENTIALLY EXPRESSED MICRORNAS; CIRCULATING MICRORNAS; CELL-PROLIFERATION; FOLLICULAR-FLUID; FAILURE PATIENTS; IDENTIFICATION; DICER1; CANCER; MIRNAS; RNAS;

D O I：

10.1016/j.fertnstert.2014.04.024

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

MicroRNAs have recently begun to be explored in ovarian cells, uncovering their influence on fundamental ovarian features like steroidogenesis, ovulation, and curpos luteum development and function. We provide a review of the current knowledge on microRNAs, specifically relating to human ovarian cell function and microRNAs' role in the ovarian physiologic process and ovulation dysfunction. Because of microRNAs' known stability in body fluids, we enlighten also their potential use in the clinical setting as novel biomarkers for ovarian function. Future research of the role of microRNAs in physiologic and dysfunctional ovulation may offer new diagnostic and treatment strategies for infertility and other ovarian disorders.

引用

页码：1524 / 1530

页数：7

共 88 条

[1]

MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing [J].