Dicer is essential for mouse development

被引：1471

作者：

Bernstein, E

Kim, SY

Carmell, MA

Murchison, EP

Alcorn, H

Li, MZ

Mills, AA

Elledge, SJ

Anderson, KV

Hannon, GJ

机构：

[1] Watson Sch Biol Sci, Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] SUNY Stony Brook, Genet Program, Stony Brook, NY 11794 USA

[3] Sloan Kettering Inst, Dev Biol Program, New York, NY 10021 USA

[4] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[5] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

来源：

NATURE GENETICS | 2003年 / 35卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ng1253

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To address the biological function of RNA interference (RNAi) related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1 - null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1 - null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

引用

页码：215 / 217

页数：3

共 15 条

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