药物性肝损伤的代谢、遗传学机制

被引：18

作者：

王书杰 ^{[1
,2
]}

王沛 ^{[2
]}

李晓天 ^{[1
]}

张莉蓉 ^{[2
]}

机构：

[1] 郑州大学药学院药理学系

[2] 郑州大学基础医学院药理学系

来源：

中国药理学通报 | 2016年 / 32卷 / 07期

关键词：

药物性肝损伤; 肝毒性; 代谢; 遗传; 白细胞抗原; CYP450;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

药物引起的肝损伤是引起急性肝功能衰竭的重要原因,也是导致治疗药物退市的主要原因。药物性肝损伤的发病机制复杂,其中以代谢、遗传学机制为主。该文综述了成人常用药物引起肝损伤的机制,并就热点问题进行讨论。旨在探讨这些研究可能的临床意义,为进一步阐明药物性肝损伤的发病机制指明方向。

引用

页码：898 / 902

页数：5

共 16 条

[1]

对乙酰氨基酚SD大鼠毒代动力学研究及P450的影响 [J].

郭秋平 ;

杨威 ;

郭琳 ;

覃仁安 ;

金若敏 .

中国药理学通报, 2014, (08) :1183-1184

[2]

Mechanisms of Phenytoin-Induced Toxicity in Freshly Isolated Rat Hepatocytes and the Protective Effects of Taurine and/or Melatonin [J].

Eghbal, Mohammad Ali ;

Taziki, Shohreh ;

Sattari, Mohammad Reza .

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2014, 28 (03) :111-118

[3]

Mechanisms of Drug-induced Liver Injury [J].

Yuan, Liyun ;

Kaplowitz, Neil .

CLINICS IN LIVER DISEASE, 2013, 17 (04) :507-+

[4]

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital [J].

Antoine, Daniel J. ;

Dear, James W. ;

Lewis, Philip Starkey ;

Platt, Vivien ;

Coyle, Judy ;

Masson, Moyra ;

Thanacoody, Ruben H. ;

Gray, Alasdair J. ;

Webb, David J. ;

Moggs, Jonathan G. ;

Bateman, D. Nicholas ;

Goldring, Christopher E. ;

Park, B. Kevin .

HEPATOLOGY, 2013, 58 (02) :777-787

[5]

Drug-Induced Liver Injury: The Role of Drug Metabolism and Transport [J].

Corsini, Alberto ;

Bortolini, Michele .

JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 53 (05) :463-474

[6]

Genetic Polymorphisms Affecting Drug Metabolism.[J].Ann K. Daly.Advances in Pharmacology.2012,

[7]

Pharmacogenetics of Drug-Induced Liver Injury [J].

Russmann, Stefan ;

Jetter, Alexander ;

Kullak-Ublick, Gerd A. .

HEPATOLOGY, 2010, 52 (02) :748-761

[8]

Mitochondrial Superoxide Dismutase and Glutathione Peroxidase in Idiosyncratic Drug-Induced Liver Injury [J].

Lucena, M. Isabel ;

Garcia-Martin, Elena ;

Andrade, Raul J. ;

Martinez, Carmen ;

Stephens, Camilla ;

Ruiz, Jhon D. ;

Ulzurrun, Eugenia ;

Carmen Fernandez, M. ;

Romero-Gomez, Manuel ;

Castiella, Augustin ;

Planas, Ramon ;

Antonio Duran, Jose ;

Melcon De Dios, Ana ;

Guarner, Carlos ;

Soriano, German ;

Borraz, Yolanda ;

Agundez, Jose A. G. .

HEPATOLOGY, 2010, 52 (01) :303-312

[9]

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury [J].

Donaldson, Peter T. ;

Daly, Ann K. ;

Henderson, Jill ;

Graham, Julia ;

Pirmohamed, Munir ;

Bernal, William ;

Day, Christopher P. ;

Aithal, Guruprasad P. .

JOURNAL OF HEPATOLOGY, 2010, 53 (06) :1049-1053

[10]

Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in a Caucasian population [J].

Leiro, Virginia ;

Fernandez-Villar, Alberto ;

Valverde, Diana ;

Constenla, Lucia ;

Vazquez, Rafael ;

Pineiro, Luis ;

Gonzalez-Quintela, Arturo .

LIVER INTERNATIONAL, 2008, 28 (06) :835-839

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