P糖蛋白与配体相互作用的结构基础及其肿瘤耐药逆转的研究

被引：14

作者：

赵青 ^{[1
,2
]}

黎燕 ^{[1
]}

彭晖 ^{[1
]}

机构：

[1] 军事医学科学院基础医学研究所四室

[2] 南开大学医学院

来源：

国际药学研究杂志 | 2010年 / 37卷 / 06期

关键词：

多药耐药; P糖蛋白; 药物外排; 逆转剂;

D O I：

10.13220/j.cnki.jipr.2010.06.011

中图分类号：

R968 [遗传药理学];

学科分类号：

100706 [药理学];

摘要：

P糖蛋白(P-glycoprotein,P-gp)是一种多药外排转运体,对控制各种抗癌药物的生物学活性具有重要意义。P-gp转运体作为生理屏障阻滞药物渗透,从而使药物发挥效应受限。传统的化疗增敏剂通过对转运体的调节可有效改善抗肿瘤药物的药代动力学并逆转多药耐药。本文将简要概述近年来有关P-gp与配体相互作用的结构信息以及肿瘤耐药逆转策略的研究进展。

引用

页码：439 / 445

页数：7

共 11 条

[1]

中药逆转P-糖蛋白介导的肿瘤多药耐药的研究进展 [J].

沈小玲 ;

胡英杰 ;

禹志领 ;

方宏勋 .

中国天然药物, 2009, 7 (06) :465-475

[2]

Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function [J].

Dai, Chun-ling ;

Liang, Yong-ju ;

Chen, Li-ming ;

Zhang, Xu ;

Deng, Wen-jing ;

Su, Xiao-dong ;

Shi, Zhi ;

Wu, Chung-pu ;

Ashby, Charles R., Jr. ;

Akiyama, Shin-ichi ;

Ambudkar, Suresh V. ;

Chen, Zhe-sheng ;

Fu, Li-wu .

BIOCHEMICAL PHARMACOLOGY, 2009, 78 (04) :355-364

[3]

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges.[J].Shukla;Wu;Ambudkar.Expert Opinion on Drug Metabolism & Toxicology.2008, 2

[4]

A phase II study of the safety and efficacy of the multidrug resistance inhibitor VX-710 combined with doxorubicin and vincristine in patients with recurrent small cell lung cancer [J].

Gandhi, Leena ;

Harding, Matthew W. ;

Neubauer, Marcus ;

Langer, Corey J. ;

Moore, Melvin ;

Ross, Helen J. ;

Johnson, Bruce E. ;

Lynch, Thomas J. .

CANCER, 2007, 109 (05) :924-932

[5]

Modulation of function of three ABC drug transporters; P-glycoprotein (ABCB1); mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin; a major metabolite of curcumin.[J].Pornngarm Limtrakul;Wanida Chearwae;Suneet Shukla;Chada Phisalphong;Suresh V. Ambudkar.Molecular and Cellular Biochemistry.2007, 1

[6]

Mechanisms and strategies to overcome multiple drug resistance in cancer [J].

Ozben, Tomris .

FEBS LETTERS, 2006, 580 (12) :2903-2909

[7]

Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux.[J].Mahesh D. Chavanpatil;Yogesh Patil;Jayanth Panyam.International Journal of Pharmaceutics.2006, 1

[8]

Pharmacophore-based discovery of ligands for drug transporters.[J].Cheng Chang;Sean Ekins;Praveen Bahadduri;Peter W. Swaan.Advanced Drug Delivery Reviews.2006, 12

[9]

Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition.[J].Alf Lamprecht;Jean-Pierre Benoit.Journal of Controlled Release.2006, 2

[10]

Combined pharma-cophore modeling;docking;and3D QSAR studies of ABCB1and ABCC1transporter inhibitors..Pajeva IK;Globish C;Wiese M;et al;.Chem Med Chem.2009, 11

← 1 2 →