Wnt/β-Catenin信号通路对肿瘤干细胞作用的研究进展

被引：18

作者：

李月雅

李凯

机构：

[1] 天津医科大学附属肿瘤医院

来源：

山东医药 | 2016年 / 56卷 / 09期

关键词：

肿瘤干细胞; WNT/β-Catenin信号通路; 乳腺癌; 结肠癌; 肺癌; 前列腺癌;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

肿瘤干细胞(CSC)存在于多种实体瘤中,是导致肿瘤复发及耐药的主要原因。Wnt/β-catenin信号通路在乳腺癌、肺癌、前列腺癌等CSC的自我更新、成瘤及分化中发挥重要作用。Wnt/β-catenin信号通路各调节点是未来复发性及难治性肿瘤治疗的潜在靶点。

引用

页码：98 / 100

页数：3

共 7 条

[1]

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling [J].

Yang, Lu ;

Tang, Hailin ;

Kong, Yanan ;

Xie, Xinhua ;

Chen, Jianping ;

Song, Cailu ;

Liu, Xiaoping ;

Ye, Feng ;

Li, Ning ;

Wang, Neng ;

Xie, Xiaoming .

STEM CELLS, 2015, 33 (10) :2913-2924

[2]

Abnormal expression of the Notch and Wnt/β-catenin signaling pathways in stem-like ALDHhiCD44+ cells correlates highly with Ki-67 expression in breast cancer [J].

Cui, Junwei ;

Li, Peng ;

Liu, Xiaoling ;

Hu, Hui ;

Wei, Wei .

ONCOLOGY LETTERS, 2015, 9 (04) :1600-1606

[3]

Wnt/β-catenin pathway in bone cancers [J].

Tian, Jian ;

He, Hongbo ;

Lei, Guanghua .

TUMOR BIOLOGY, 2014, 35 (10) :9439-9445

[4]

Downregulation of GSK3β by miR-544a to maintain self-renewal ability of lung caner stem cells [J].

Mo, Xiao-Mei ;

Li, Hua-Hui ;

Liu, Ming ;

Li, Yan-Tuan .

ONCOLOGY LETTERS, 2014, 8 (04) :1731-1734

[5]

Inhibition of androgen receptor and β-catenin activity in prostate cancer [J].

Lee, Eugine ;

Madar, Aviv ;

David, Gregory ;

Garabedian, Michael J. ;

DasGupta, Ramanuj ;

Logan, Susan K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (39) :15710-15715

[6]

Immunology of cancer stem cells in solid tumours. A review [J].

Maccalli, Cristina ;

Volonte, Andrea ;

Cimminiello, Carolina ;

Parmiani, Giorgio .

EUROPEAN JOURNAL OF CANCER, 2014, 50 (03) :649-655

[7]

Wnt/β-catenin signaling regulates cancer stem cells in lung cancer A549 cells [J].

Teng, Ying ;

Wang, Xiuwen ;

Wang, Yawei ;

Ma, Daoxin .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 392 (03) :373-379

← 1 →