HepaRG细胞的生物学特点及其应用

被引：23

作者：

蒋黎

王宇明

机构：

[1] 第三军医大学西南医院全军感染病研究所

来源：

肝脏 | 2010年 / 15卷 / 05期

关键词：

D O I：

10.14000/j.cnki.issn.1008-1704.2010.05.002

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

引用

页码：380 / 383

页数：4

共 8 条

[1]

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression [J].

Legendre, Claire ;

Hori, Tamaki ;

Loyer, Pascal ;

Aninat, Caroline ;

Ishida, Seiichi ;

Glaise, Denise ;

Lucas-Clerc, Catherine ;

Boudjema, Karim ;

Guguen-Guillouzo, Christiane ;

Corlu, Anne ;

Morel, Fabrice .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (16) :2882-2892

[2]

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells [J].

Turpeinen, Miia ;

Tolonen, Ari ;

Chesne, Christophe ;

Guillouzo, Andre ;

Uusitalo, Jouko ;

Pelkonen, Olavi .

TOXICOLOGY IN VITRO, 2009, 23 (04) :748-753

[3]

Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions [J].

Lambert, Carine B. ;

Spire, Catherine ;

Renaud, Marie-Pierre ;

Claude, Nancy ;

Guillouzo, Andre .

TOXICOLOGY IN VITRO, 2009, 23 (03) :466-475

[4]

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation [J].

Zanger, Ulrich M. ;

Turpeinen, Miia ;

Klein, Kathrin ;

Schwab, Matthias .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 392 (06) :1093-1108

[5]

Inhibition and induction of human cytochrome P450 enzymes: current status [J].

Pelkonen, Olavi ;

Turpeinen, Miia ;

Hakkola, Jukka ;

Honkakoski, Paavo ;

Hukkanen, Janne ;

Raunio, Hannu .

ARCHIVES OF TOXICOLOGY, 2008, 82 (10) :667-715

[6]

The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics [J].

Guillouzo, Andre ;

Corlu, Anne ;

Aninat, Caroline ;

Glaise, Denise ;

Morel, Fabrice ;

Guguen-Guillouzo, Christiane .

CHEMICO-BIOLOGICAL INTERACTIONS, 2007, 168 (01) :66-73

[7]

CYP4A11 is repressed by retinoic acid in human liver cells [J].

Antoun, Joseph ;

Amet, Yolande ;

Simon, Brigitte ;

Dréano, Yvonne ;

Corlu, Anne ;

Corcos, Laurent ;

Salaun, Jean Pierre ;

Plée-Gautier, Emmanuelle .

FEBS LETTERS, 2006, 580 (14) :3361-3367

[8]

Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge.[J].S Knasmüller;V Mersch-Sundermann;S Kevekordes;F Darroudi;W.W Huber;C Hoelzl;J Bichler;B.J Majer.Toxicology.2004, 1

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