慢性自发性荨麻疹血清脱氢表雄酮硫酸酯与总IgE,IL-2,IL-4,IFN-γ的相关性

被引：17

作者：

胡月 ^{[1
]}

赵海春 ^{[2
]}

安国芝 ^{[3
]}

陈雷刚 ^{[3
]}

机构：

[1] 河北北方学院

[2] 河北北方学院附属第一医院检验科

[3] 河北北方学院附属第一医院皮肤科

来源：

中国皮肤性病学杂志 | 2016年 / 30卷 / 10期

关键词：

慢性自发性荨麻疹; 血清脱氢表雄酮硫酸酯; Ig E; 白介素-2; 白介素-4; 干扰素-γ;

D O I：

10.13735/j.cjdv.1001-7089.201601129

中图分类号：

R758.24 [荨麻疹];

学科分类号：

100227 [皮肤病学];

摘要：

目的通过研究慢性自发性荨麻疹(CSU)患者与健康对照组血清脱氢表雄酮硫酸酯(DHEA-S)及总IgE,IL-2,IL-4,IFN-γ水平的差异,探讨CSU患者外周血DHEA-S是否与总IgE、Th1/Th2细胞失衡相关。方法 162例CSU患者为实验组,68例健康人为对照组。应用放射免疫分析法测定血清中DHEA-S水平;采用ELISA法检测外周血总IgE,IL-2,IL-4,IFN-γ水平。采用t检验和直线相关性分析分析各组检测值。结果 CSU组外周血DHEA-S,IL-2,IFN-γ水平明显低于健康对照组,血清总IgE,IL-4水平明显高于健康对照组,差异有统计学意义(P<0.05)。CSU病情分级与DHEA-S水平呈负相关,与总IgE水平呈正相关(r=-0.664,-0.419,P均<0.01),与IL-2,IL-4,IFN-γ水平无明显相关性。CSU组DHEA-S与IL-2,IFN-γ呈显著正相关,与IgE,IL-4呈显著负相关(r=0.409,0.397,-0.319,-0.367,P均<0.001)。结论 CSU患者体内可能存在内分泌免疫系统失衡,外周血DHEA-S水平下降可能与总IgE水平升高及Th1/Th2细胞失衡相关。

引用

页码：1007 / 1009+1013 +1013

页数：4

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