性激素对腹部外科疾病伴全身炎症反应综合征患者预后的影响

被引：4

作者：

巩传勇 ^{[1
]}

傅强 ^{[1
]}

杜超 ^{[1
]}

机构：

[1] 天津医科大学天津市南开医院外科重症监护病房

来源：

中国危重病急救医学 | 2011年 / 11期

关键词：

雌二醇; 泌乳素; 睾酮; 腹部外科; 全身炎症反应综合征;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100218 ;

摘要：

目的评价血清性激素水平在腹部外科疾病伴全身炎症反应综合征(SIRS)患者病情预后评估中的应用价值。方法采用前瞻性、单中心、观察研究方法。选择2009年7月10日至2010年2月9日天津市南开医院外科重症监护病房(SICU)收治的39例腹部外科疾病伴SIRS患者,根据患者入院72 h内的血清雌二醇、泌乳素及睾酮水平(用放射免疫法检测)分为雌二醇升高组(20例)和未升高组(19例)、泌乳素升高组(16例)和未升高组(23例)、睾酮降低组(14例)和未降低组(25例),分别观察各组患者急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、总住院时间、住ICU时间、总住院费用及28 d转归。结果与雌二醇未升高组比较,雌二醇升高组APACHEⅡ评分(分)有所降低,但差异无统计学意义(11.6±7.8比15.2±8.8,P>0.05),住ICU时间(d)明显缩短(8.5±4.0比12.1±7.9,P<0.05),28 d病死率明显降低(10.0%比35.7%,P<0.05)。与泌乳素未升高组比较,泌乳素升高组住ICU时间(d)明显缩短(8.7±3.1比12.9±2.1,P<0.01),总住院费用(万元)明显降低(6.70±3.50比13.20±8.20,P<0.05)。与睾酮未降低组比较,睾酮降低组APACHEⅡ评分(分)明显降低(10.4±5.4比15.2±9.4,P<0.05),住ICU时间(d)明显缩短(26.6±12.2比28.1±17.0,P<0.01),28 d病死率明显降低(0比31.8%,P<0.01)。结论腹部外科疾病伴SIRS患者早期血清雌激素、泌乳素及睾酮水平对患者的预后有显著影响。

引用

共 30 条

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