计算机辅助认知训练对帕金森病患者认知功能的影响

被引：18

作者：

韩小改 ^{[1
]}

李学 ^{[2
]}

李林忆 ^{[2
]}

单泓 ^{[1
]}

别立莉 ^{[1
]}

马建军 ^{[2
]}

机构：

[1] 河南省红十字血液中心

[2] 河南省人民医院神经内科郑州大学人民医院河南大学人民医院

来源：

中国实用神经疾病杂志 | 2019年 / 22卷 / 16期

关键词：

帕金森病; 计算机辅助认知训练; 认知功能; 抑郁; P300;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

目的观察计算机辅助认知训练对伴轻度认知功能障碍的帕金森病(Parkinson's disease with mild cognitive impairment,PD-MCI)患者认知功能的影响。方法选取PD-MCI患者111例,采用随机数字表法将其分为观察组(56例)及对照组(55例)。2组患者均给予常规抗PD药物治疗,同时对照组接受一般认知训练,观察组接受计算机辅助认知训练。于训练前、治疗6周后对2组蒙特利尔认知评测量表(MoCA)、统一PD评价量表(UPDRS)、汉密尔顿抑郁量表(HMDS)、PD生活质量量表-39(PDQ-39)等评分及P300进行评估。结果治疗前,2组MoCA总分、UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ、HMDS和PDQ-39等评分组间差异均无统计学意义(P>0.05)。治疗后,2组MoCA总分、UPDRS-Ⅰ、UPDRS-Ⅱ、HMDS和PDQ-39等评分均较治疗前显著改善(P<0.05),观察组MoCA总分、UPDRS-Ⅰ、UPDRS-Ⅱ、HMDS和PDQ-39评分显著优于对照组(P<0.05)。对MoCA评分进步一分析,治疗后2组视空间与执行功能、延迟记忆、注意力、抽象、语言、定向力等得分较治疗前显著提高(P<0.05),且观察组视空间与执行功能、注意力、抽象、定向力等评分亦显著优于对照组(P<0.05)。治疗前,2组P300潜伏期、波幅比较差异无统计学意义(P>0.05);治疗后2组P300潜伏期显著缩短(P<0.05),P300波幅明显增加(P<0.05),且观察组P300潜伏期、波幅与对照组比较差异均有统计学意义(P<0.05)。结论计算机辅助认知训练可显著改善PD患者的认知功能和抑郁症状,提高生活质量。

引用

页码：1826 / 1832

页数：7

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